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Is depression a global brain disorder with topographic dynamic reorganization?
- Source :
-
Translational psychiatry [Transl Psychiatry] 2024 Jul 05; Vol. 14 (1), pp. 278. Date of Electronic Publication: 2024 Jul 05. - Publication Year :
- 2024
-
Abstract
- Major depressive disorder (MDD) is characterized by a multitude of psychopathological symptoms including affective, cognitive, perceptual, sensorimotor, and social. The neuronal mechanisms underlying such co-occurrence of psychopathological symptoms remain yet unclear. Rather than linking and localizing single psychopathological symptoms to specific regions or networks, this perspective proposes a more global and dynamic topographic approach. We first review recent findings on global brain activity changes during both rest and task states in MDD showing topographic reorganization with a shift from unimodal to transmodal regions. Next, we single out two candidate mechanisms that may underlie and mediate such abnormal uni-/transmodal topography, namely dynamic shifts from shorter to longer timescales and abnormalities in the excitation-inhibition balance. Finally, we show how such topographic shift from unimodal to transmodal regions relates to the various psychopathological symptoms in MDD including their co-occurrence. This amounts to what we describe as 'Topographic dynamic reorganization' which extends our earlier 'Resting state hypothesis of depression' and complements other models of MDD.<br /> (© 2024. The Author(s).)
Details
- Language :
- English
- ISSN :
- 2158-3188
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Translational psychiatry
- Publication Type :
- Academic Journal
- Accession number :
- 38969642
- Full Text :
- https://doi.org/10.1038/s41398-024-02995-9