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Evaluation of the value of combined thyroid function-related indexes in the prognosis prediction of patients with differentiated thyroid cancer.
- Source :
-
Medicine [Medicine (Baltimore)] 2024 Jul 05; Vol. 103 (27), pp. e38787. - Publication Year :
- 2024
-
Abstract
- This study aims to evaluate the prognostic significance of thyroid function-related indices in patients with differentiated thyroid cancer (DTC). This retrospective analysis included 90 patients diagnosed with DTC and treated at our hospital from January 2010 to January 2019. Patients were classified into 2 groups based on whole-body imaging results: 67 with a favorable prognosis and 23 with a poor prognosis. The study compared clinical data and thyroid function indices between these groups to assess their efficacy in prognostic prediction. Patients in the poor prognosis group had a higher occurrence of T3-4 stage cancer (P = .006) and ≥2 lymph node metastases (P = .019). Notably, levels of total thyroxine (TT4), thyroid-stimulating hormone (TSH), and thyroglobulin antibody (Tg-Ab) were significantly elevated in this group (P < .001 for each). Receiver operating characteristic analysis revealed substantial predictive accuracy for TT4, TSH, and Tg-Ab (area under curve of 0.747, 0.820, and 0.720, respectively). The columnar graphical model used for prediction demonstrated a high concordance index (C-index = 0.919), superior to single-indicator evaluations. Thyroid function indices, specifically TT4, TSH, and Tg-Ab, play a crucial role in the prognostic assessment of patients with DTC. The column-line diagram model effectively enhances prophetic prediction, aiding in clinical decision-making.<br />Competing Interests: The authors have no funding and conflicts of interest to disclose.<br /> (Copyright © 2024 the Author(s). Published by Wolters Kluwer Health, Inc.)
- Subjects :
- Humans
Male
Female
Retrospective Studies
Middle Aged
Prognosis
Adult
Thyroxine blood
Autoantibodies blood
Aged
ROC Curve
Thyroid Gland pathology
Thyroid Gland physiopathology
Thyroid Gland diagnostic imaging
Lymphatic Metastasis
Neoplasm Staging
Thyroglobulin blood
Thyroid Neoplasms pathology
Thyroid Neoplasms mortality
Thyroid Neoplasms blood
Thyrotropin blood
Thyroid Function Tests
Subjects
Details
- Language :
- English
- ISSN :
- 1536-5964
- Volume :
- 103
- Issue :
- 27
- Database :
- MEDLINE
- Journal :
- Medicine
- Publication Type :
- Academic Journal
- Accession number :
- 38968461
- Full Text :
- https://doi.org/10.1097/MD.0000000000038787