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The role of adipokines in the pathogenesis of psoriasis - a focus on resistin, omentin-1 and vaspin.

Authors :
Kiełbowski K
Bakinowska E
Bratborska AW
Pawlik A
Source :
Expert opinion on therapeutic targets [Expert Opin Ther Targets] 2024 Jul; Vol. 28 (7), pp. 587-600. Date of Electronic Publication: 2024 Jul 05.
Publication Year :
2024

Abstract

Background: Psoriasis is a chronic immune-mediated skin condition with several types of manifestation, including psoriatic arthritis. In recent years, studies have demonstrated multiple molecules and mechanisms that play important roles in the pathophysiology of psoriasis. Studies have been conducted to determine the role of adipokines, bioactive peptides secreted by the adipose tissue, in the pathogenesis of inflammatory diseases. These studies have shown that adipokines are dysregulated in psoriasis and their abnormal expression profile could contribute to the inflammatory mechanisms observed in psoriasis.<br />Areas Covered: In this review, we discuss the immunomodulatory features of resistin, omentin-1, and vaspin, and discuss their potential involvement in the pathogenesis of psoriasis.<br />Expert Opinion: The adipokines resistin, omentin, and vaspin appear to be promising therapeutic targets in psoriasis. It is important to seek to block the action of resistin, either by blocking its receptors or by blocking its systemic effects with antibodies. In the case of omentin and vaspin, substances that are receptor mimetics of these adipokines should be sought and studies conducted of their analogues for the treatment of psoriasis. To introduce these therapies into clinical practice, multicentre clinical trials are required to confirm their efficacy and safety after initial studies in animal models.

Details

Language :
English
ISSN :
1744-7631
Volume :
28
Issue :
7
Database :
MEDLINE
Journal :
Expert opinion on therapeutic targets
Publication Type :
Academic Journal
Accession number :
38965991
Full Text :
https://doi.org/10.1080/14728222.2024.2375373