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Increased percentage of HLA-DR T cells in untreated juvenile dermatomyositis.
- Source :
-
Clinical immunology communications [Clin Immunol Commun] 2024 Jun; Vol. 5, pp. 20-25. Date of Electronic Publication: 2024 Feb 22. - Publication Year :
- 2024
-
Abstract
- This study investigates HLA-DR expression on activated T cells and serum neopterin levels in Juvenile Dermatomyositis (JDM) children pre- and post-treatment. Sixty-nine JDM children (less than 18 years) were included. Elevated HLA-DR+ T cells (>7 %) were observed in 19 % of untreated cases. Post-treatment, mean HLA-DR+ T cells decreased from 5.1 to 2.9 ( P < 0.001), and serum neopterin levels declined from 19.3 to 9.1 nmol/L ( P < 0.0001). A positive correlation between serum neopterin and HLA-DR T cell percentage was observed ( r = 0.39, P = 0.01). Intravenous steroid treatment exhibited a 47.4 % improvement in HLA-DR+ T cells and a 50.5 % reduction in serum neopterin levels, in contrast to 14.8 % and 34.1 % in the oral steroid group. In conclusion, treatment, particularly with IV steroids, significantly improved HLA-DR+ T cells percentage and neopterin levels. A correlation between HLA-DR+ T cells percentage and serum neopterin was noted in untreated JDM patients.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Details
- Language :
- English
- ISSN :
- 2772-6134
- Volume :
- 5
- Database :
- MEDLINE
- Journal :
- Clinical immunology communications
- Publication Type :
- Academic Journal
- Accession number :
- 38962376
- Full Text :
- https://doi.org/10.1016/j.clicom.2024.02.002