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Propanediamine modified pillar[5]arene: A novel stationary phase for the high selectivity separation of versatile analytes.
- Source :
-
Journal of chromatography. A [J Chromatogr A] 2024 Aug 16; Vol. 1730, pp. 465134. Date of Electronic Publication: 2024 Jun 30. - Publication Year :
- 2024
-
Abstract
- The unique properties of pillar[5]arene, including hydrophobic cavities, π-π conjugated and easy modification, make it a promising candidate as stationary phase for HPLC. Herein, we fabricated a novel propanediamine modified pillar[5]arene bonded silica as the stationary phase (PDA-BP5S) for reversed-phase liquid chromatography (RPLC). Benefiting from the significant hydrophobicity, π-π conjugative, p-π effect, and hydrogen bonding, the PDA-BP5S packed column showed high separation performance of versatile analytes involving polycyclic aromatic hydrocarbons, alkyl benzenes, phenols, arylamine, phenylethane/styrene/ phenylacetylene, toluene/m-xylene/mesitylene, halobenzenes, benzenediol and nitrophenol isomers. Especially, the separation of halobenzenes appeared to be controlled by both the size of the halogen substituents and the strength of the noncovalent bonding interactions, which was further confirmed by molecular dynamics simulation. The satisfactory separation and repeatability revealed the promising prospects of amine-pillar[5]arene-based stationary phase for RPLC.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Subjects :
- Molecular Dynamics Simulation
Quaternary Ammonium Compounds chemistry
Chromatography, High Pressure Liquid methods
Silicon Dioxide chemistry
Hydrogen Bonding
Polycyclic Aromatic Hydrocarbons isolation & purification
Polycyclic Aromatic Hydrocarbons analysis
Polycyclic Aromatic Hydrocarbons chemistry
Chromatography, Reverse-Phase methods
Calixarenes chemistry
Hydrophobic and Hydrophilic Interactions
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3778
- Volume :
- 1730
- Database :
- MEDLINE
- Journal :
- Journal of chromatography. A
- Publication Type :
- Academic Journal
- Accession number :
- 38959655
- Full Text :
- https://doi.org/10.1016/j.chroma.2024.465134