Back to Search
Start Over
No energy, no autophagy-Mechanisms and therapeutic implications of autophagic response energy requirements.
- Source :
-
Journal of cellular physiology [J Cell Physiol] 2024 Jul 03, pp. e31366. Date of Electronic Publication: 2024 Jul 03. - Publication Year :
- 2024
- Publisher :
- Ahead of Print
-
Abstract
- Autophagy is a lysosome-mediated self-degradation process of central importance for cellular quality control. It also provides macromolecule building blocks and substrates for energy metabolism during nutrient or energy deficiency, which are the main stimuli for autophagy induction. However, like most biological processes, autophagy itself requires ATP, and there is an energy threshold for its initiation and execution. We here present the first comprehensive review of this often-overlooked aspect of autophagy research. The studies in which ATP deficiency suppressed autophagy in vitro and in vivo were classified according to the energy pathway involved (oxidative phosphorylation or glycolysis). A mechanistic insight was provided by pinpointing the critical ATP-consuming autophagic events, including transcription/translation/interaction of autophagy-related molecules, autophagosome formation/elongation, autophagosome fusion with the lysosome, and lysosome acidification. The significance of energy-dependent fine-tuning of autophagic response for preserving the cell homeostasis, and potential implications for the therapy of cancer, autoimmunity, metabolic disorders, and neurodegeneration are discussed.<br /> (© 2024 Wiley Periodicals LLC.)
Details
- Language :
- English
- ISSN :
- 1097-4652
- Database :
- MEDLINE
- Journal :
- Journal of cellular physiology
- Publication Type :
- Academic Journal
- Accession number :
- 38958520
- Full Text :
- https://doi.org/10.1002/jcp.31366