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A multicenter protocol to assess the prognostic significance of the tumor microenvironment in patients with squamous cell carcinoma of the larynx.
- Source :
-
Head & neck [Head Neck] 2024 Sep; Vol. 46 (9), pp. 2123-2131. Date of Electronic Publication: 2024 Jul 03. - Publication Year :
- 2024
-
Abstract
- Background: The purpose of this multicenter study was to retrospectively investigate the prognostic significance of the tumor microenvironment, in relation to survival in a large cohort of patients with laryngeal squamous cell carcinoma (LSCC), using the method proposed by the International TILs Working Group in breast cancer.<br />Methods: All consecutive patients with biopsy-proven LSCC who underwent total laryngectomy (TL) between January 2014 and January 2023 were retrospectively included in the study. A retrospective review of medical records including surgical, pathological and follow-up reports was performed. The density of TILs was determined according to the recommendations of the International TILs Working Group.<br />Results: The study group included 186 patients with LSCC. High TILs were statistically correlated with reduced size and extension of primary tumor (pT stage) with a statistically significant value (S: p = 0.01; P: p = 0.0003) and without needs of salvage therapy (S: p = 0.03; P: p = 0.004). Low TILs were indicative of worse prognosis.<br />Conclusions: Our study confirmed the protective value of TILs and the prognostic role of the tumor microenvironment in LSCC; furthermore, our results showed that the score proposed by the International TILs Working Group for breast cancer can be applied to LSCC.<br /> (© 2024 Wiley Periodicals LLC.)
- Subjects :
- Humans
Female
Retrospective Studies
Middle Aged
Male
Prognosis
Aged
Adult
Lymphocytes, Tumor-Infiltrating
Aged, 80 and over
Neoplasm Staging
Survival Analysis
Laryngeal Neoplasms pathology
Laryngeal Neoplasms mortality
Laryngeal Neoplasms surgery
Tumor Microenvironment immunology
Carcinoma, Squamous Cell pathology
Carcinoma, Squamous Cell mortality
Carcinoma, Squamous Cell surgery
Laryngectomy
Subjects
Details
- Language :
- English
- ISSN :
- 1097-0347
- Volume :
- 46
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Head & neck
- Publication Type :
- Academic Journal
- Accession number :
- 38958199
- Full Text :
- https://doi.org/10.1002/hed.27860