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miR-15a targets the HSP90 co-chaperone Morgana in chronic myeloid leukemia.
- Source :
-
Scientific reports [Sci Rep] 2024 Jul 02; Vol. 14 (1), pp. 15089. Date of Electronic Publication: 2024 Jul 02. - Publication Year :
- 2024
-
Abstract
- Morgana is a ubiquitous HSP90 co-chaperone protein coded by the CHORDC1 gene. Morgana heterozygous mice develop with age a myeloid malignancy resembling human atypical myeloid leukemia (aCML), now renamed MDS/MPN with neutrophilia. Patients affected by this pathology exhibit low Morgana levels in the bone marrow (BM), suggesting that Morgana downregulation plays a causative role in the human malignancy. A decrease in Morgana expression levels is also evident in the BM of a subgroup of Philadelphia-positive (Ph+) chronic myeloid leukemia (CML) patients showing resistance or an incomplete response to imatinib. Despite the relevance of these data, the mechanism through which Morgana expression is downregulated in patients' bone marrow remains unclear. In this study, we investigated the possibility that Morgana expression is regulated by miRNAs and we demonstrated that Morgana is under the control of four miRNAs (miR-15a/b and miR-26a/b) and that miR-15a may account for Morgana downregulation in CML patients.<br /> (© 2024. The Author(s).)
- Subjects :
- Animals
Humans
Mice
Bone Marrow metabolism
Bone Marrow pathology
Down-Regulation
Gene Expression Regulation, Leukemic
Molecular Chaperones metabolism
Molecular Chaperones genetics
HSP90 Heat-Shock Proteins metabolism
HSP90 Heat-Shock Proteins genetics
Leukemia, Myelogenous, Chronic, BCR-ABL Positive genetics
Leukemia, Myelogenous, Chronic, BCR-ABL Positive metabolism
Leukemia, Myelogenous, Chronic, BCR-ABL Positive pathology
MicroRNAs genetics
MicroRNAs metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 38956394
- Full Text :
- https://doi.org/10.1038/s41598-024-65404-7