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Effect of Modified Forms of Sodium Humate PowHumus on the Balance of Arginine in Peritoneal Macrophages of Intact Mice.
- Source :
-
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2024 May; Vol. 177 (1), pp. 68-73. Date of Electronic Publication: 2024 Jul 02. - Publication Year :
- 2024
-
Abstract
- Substances of silver nanoparticles dialyzed through a 13 kDa membrane, synthesized in a medium of humic ligands modified with hydroquinone and 2-hydroxynaphthoquinone from PowHumus brown coal, specifically enhance the M2 properties of peritoneal macrophages due to inhibition of NO synthase and significant activation of arginase, thus enhancing anti-inflammatory properties of cells. In small, but effective concentrations, they do not have cytotoxic properties and do not contain pyrogenic impurities. The studied humates are able to influence the mechanisms of immune response formation and are an effective means for correcting inflammation and regeneration.<br /> (© 2024. Springer Science+Business Media, LLC, part of Springer Nature.)
- Subjects :
- Animals
Mice
Metal Nanoparticles chemistry
Hydroquinones pharmacology
Hydroquinones chemistry
Male
Nitric Oxide metabolism
Nitric Oxide Synthase metabolism
Naphthoquinones pharmacology
Naphthoquinones chemistry
Macrophages, Peritoneal drug effects
Macrophages, Peritoneal metabolism
Arginine pharmacology
Arginine chemistry
Arginase metabolism
Silver chemistry
Silver pharmacology
Humic Substances
Subjects
Details
- Language :
- English
- ISSN :
- 1573-8221
- Volume :
- 177
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Bulletin of experimental biology and medicine
- Publication Type :
- Academic Journal
- Accession number :
- 38955855
- Full Text :
- https://doi.org/10.1007/s10517-024-06133-9