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Drug delivery strategies through 3D-printed calcium phosphate.
- Source :
-
Trends in biotechnology [Trends Biotechnol] 2024 Nov; Vol. 42 (11), pp. 1396-1409. Date of Electronic Publication: 2024 Jul 02. - Publication Year :
- 2024
-
Abstract
- 3D printing has revolutionized bone tissue engineering (BTE) by enabling the fabrication of patient- or defect-specific scaffolds to enhance bone regeneration. The superior biocompatibility, customizable bioactivity, and biodegradability have enabled calcium phosphate (CaP) to gain significance as a bone graft material. 3D-printed (3DP) CaP scaffolds allow precise drug delivery due to their porous structure, adaptable structure-property relationship, dynamic chemistry, and controlled dissolution. The effectiveness of conventional scaffold-based drug delivery is hampered by initial burst release and drug loss. This review summarizes different multifunctional drug delivery approaches explored in controlling drug release, including polymer coatings, formulation integration, microporous scaffold design, chemical crosslinking, and direct extrusion printing for BTE applications. The review also outlines perspectives and future challenges in drug delivery research, paving the way for next-generation bone repair methodologies.<br />Competing Interests: Declaration of interests No interests are declared.<br /> (Copyright © 2024 Elsevier Ltd. All rights reserved.)
Details
- Language :
- English
- ISSN :
- 1879-3096
- Volume :
- 42
- Issue :
- 11
- Database :
- MEDLINE
- Journal :
- Trends in biotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 38955569
- Full Text :
- https://doi.org/10.1016/j.tibtech.2024.05.006