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A Multifunctional Nanocatalytic Metal-Organic Framework as a Ferroptosis Amplifier for Mild Hyperthermia Photothermal Therapy.
- Source :
-
Research (Washington, D.C.) [Research (Wash D C)] 2024 Jul 01; Vol. 7, pp. 0397. Date of Electronic Publication: 2024 Jul 01 (Print Publication: 2024). - Publication Year :
- 2024
-
Abstract
- Hyperthermia therapy is considered an effective anticancer strategy. However, high temperature can trigger an excessive inflammatory response, leading to tumor self-protection, immunosuppression, metastasis, and recurrence. To address this issue, we reported a multifunctional photothermal nanoplatform to achieve mild hyperthermia photothermal therapy (mild PTT) based on cisplatin (DDP) and a ferrocene metal-organic framework (MOF-Fc) nanocomposite, which can specifically enhance ferroptosis-triggered oxidative stress levels and synchronously amplify mild hyperthermia PTT-mediated anticancer responses. Both in vitro and in vivo antineoplastic results verify the superiority of mild PTT with DDP/MOF-Fc@HA. The combination of DDP and MOF-Fc exhibits Fenton catalytic activity and glutathione depletion capacity, magnifying mild hyperthermia effects via the radical oxygen species (ROS)-adenosine triphosphate (ATP)-HSP silencing pathway, with important implications for clinical hyperthermia therapy.<br />Competing Interests: Competing interests: The authors declare that they have no competing interests.<br /> (Copyright © 2024 Ying Deng et al.)
Details
- Language :
- English
- ISSN :
- 2639-5274
- Volume :
- 7
- Database :
- MEDLINE
- Journal :
- Research (Washington, D.C.)
- Publication Type :
- Academic Journal
- Accession number :
- 38952997
- Full Text :
- https://doi.org/10.34133/research.0397