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Endogenous Fe 2+ -triggered self-targeting nanomicelles for self-amplifying intracellular oxidative stress.
- Source :
-
Animal models and experimental medicine [Animal Model Exp Med] 2024 Jul 01. Date of Electronic Publication: 2024 Jul 01. - Publication Year :
- 2024
- Publisher :
- Ahead of Print
-
Abstract
- Background: Artesunate (ASA) acts as an •O₂ <superscript>-</superscript> source through the breakdown of endoperoxide bridges catalyzed by Fe <superscript>2+</superscript> , yet its efficacy in ASA-based nanodrugs is limited by poor intracellular delivery.<br />Methods: ASA-hyaluronic acid (HA) conjugates were formed from hydrophobic ASA and hydrophilic HA by an esterification reaction first, and then self-targeting nanomicelles (NM) were developed using the fact that the amphiphilic conjugates of ASA and HA are capable of self-assembling in aqueous environments.<br />Results: These ASA-HA NMs utilize CD44 receptor-mediated transcytosis to greatly enhance uptake by breast cancer cells. Subsequently, endogenous Fe <superscript>2+</superscript> from the tumor catalyzes the released ASA to produce highly toxic •O₂ <superscript>-</superscript> radicals to kill tumor cells, although sustained tumor growth inhibition can be achieved via in vivo experiments.<br />Conclusions: Self-targeting NMs represent a promising strategy for enhancing ASA-based treatments, leveraging clinically approved drugs to expedite drug development and clinical research in oncology.<br /> (© 2024 The Author(s). Animal Models and Experimental Medicine published by John Wiley & Sons Australia, Ltd on behalf of The Chinese Association for Laboratory Animal Sciences.)
Details
- Language :
- English
- ISSN :
- 2576-2095
- Database :
- MEDLINE
- Journal :
- Animal models and experimental medicine
- Publication Type :
- Academic Journal
- Accession number :
- 38952042
- Full Text :
- https://doi.org/10.1002/ame2.12468