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The effect of cyclosporine a in pterygium surgery using fibrin glue.
- Source :
-
International ophthalmology [Int Ophthalmol] 2024 Jun 29; Vol. 44 (1), pp. 297. Date of Electronic Publication: 2024 Jun 29. - Publication Year :
- 2024
-
Abstract
- Background/objectives: To evaluate the effect of topical cyclosporine A (CsA) 0.05% in patients with pterygium surgery using fibrin glue (FG).<br />Subjects/methods: Patients with primary nasal pterygium were retrospectically analyzed and categorized into two groups: Group 1 with 41 eyes from 38 patients as a control group and group 2 with 39 eyes from 36 patients who received topical CsA twice a day for 6 months. Patients were assessed for recurrence rate, tear film parameters, side effects, and complications at postoperative intervals of 1-7 days; 1st, 3rd, 6th and 12th months. The follow-up period was 1 year.<br />Results: The two groups were age (p = 0.934) and sex (p = 0.996) matched. CsA drop was discontinued in one patient due to burning sensation and conjunctival hyperemia after 1 week. There was no statistically significant difference between the mean preoperative and postoperative 1st year Schirmer I and tear break-up time (TBUT) values in group 1 (p = 0.136; p = 0.069). Although the difference between the mean preoperative and postoperative 1st year TBUT values in group 2 was not statistically different (p = 0.249), Schirmer I results were higher postoperatively (p = 0.003). There was no statistically significant difference between preoperative Schirmer (p = 0.496), postoperative Schirmer (p = 0.661), preoperative TBUT (p = 0.240) and postoperative TBUT (p = 0.238) results of the two groups. Recurrence was observed in only one patient from group 1.<br />Conclusion: No recurrent pterygium cases were observed in group 2. Schirmer I values were higher postoperatively in group 2; thus,topical CsA treatment may improve lacrimal secretion and be effective after pterygium surgery with FG.<br /> (© 2024. The Author(s), under exclusive licence to Springer Nature B.V.)
- Subjects :
- Humans
Male
Female
Middle Aged
Retrospective Studies
Follow-Up Studies
Adult
Tissue Adhesives administration & dosage
Tissue Adhesives therapeutic use
Treatment Outcome
Aged
Ophthalmic Solutions administration & dosage
Ophthalmologic Surgical Procedures methods
Ophthalmologic Surgical Procedures adverse effects
Recurrence
Conjunctiva
Tears metabolism
Tears physiology
Pterygium surgery
Pterygium diagnosis
Cyclosporine administration & dosage
Fibrin Tissue Adhesive administration & dosage
Immunosuppressive Agents administration & dosage
Subjects
Details
- Language :
- English
- ISSN :
- 1573-2630
- Volume :
- 44
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- International ophthalmology
- Publication Type :
- Academic Journal
- Accession number :
- 38951293
- Full Text :
- https://doi.org/10.1007/s10792-024-03170-1