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A review on polyamines as promising next-generation neuroprotective and anti-aging therapy.

A review on polyamines as promising next-generation neuroprotective and anti-aging therapy.

Authors :
Arthur R
Jamwal S
Kumar P
Source :
European journal of pharmacology [Eur J Pharmacol] 2024 Sep 05; Vol. 978, pp. 176804. Date of Electronic Publication: 2024 Jun 29.
Publication Year :
2024

Abstract

Neurodegenerative disorders are diseases characterized by progressive degeneration of neurons and associated structures and are a major global issue growing more widespread as the global population's average age increases. Despite several investigations on their etiology, the specific cause of these disorders remains unknown. However, there are few symptomatic therapies to treat these disorders. Polyamines (PAs) (putrescine, spermidine, and spermine) are being studied for their role in neuroprotection, aging and cognitive impairment. They are ubiquitous polycations which have relatively higher concentrations in the brain and possess pleiotropic biochemical activities, including regulation of gene expression, ion channels, mitochondria Ca <superscript>2+</superscript> transport, autophagy induction, programmed cell death, and many more. Their cellular content is tightly regulated, and substantial evidence indicates that their altered levels and metabolism are strongly implicated in aging, stress, cognitive dysfunction, and neurodegenerative disorders. In addition, dietary polyamine supplementation has been reported to induce anti-aging effects, anti-oxidant effects, and improve locomotor abnormalities, and cognitive dysfunction. Thus, restoring the polyamine level is considered a promising pharmacological strategy to counteract neurodegeneration. This review highlights PAs' physiological role and the molecular mechanism underpinning their proposed neuroprotective effect in aging and neurodegenerative disorders.<br />Competing Interests: Declaration of competing interest Authors declare no known conflict of interest whatsoever.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)

Details

Language :
English
ISSN :
1879-0712
Volume :
978
Database :
MEDLINE
Journal :
European journal of pharmacology
Publication Type :
Academic Journal
Accession number :
38950837
Full Text :
https://doi.org/10.1016/j.ejphar.2024.176804