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Recent advances in the molecular design and applications of viral RNA-targeting antiviral modalities.

Authors :
Dai J
Jiang X
da Silva-Júnior EF
Du S
Liu X
Zhan P
Source :
Drug discovery today [Drug Discov Today] 2024 Aug; Vol. 29 (8), pp. 104074. Date of Electronic Publication: 2024 Jun 29.
Publication Year :
2024

Abstract

Pathogenic viruses are a profound threat to global public health, underscoring the urgent need for the development of efficacious antiviral therapeutics. The advent of RNA-targeting antiviral strategies has marked a significant paradigm shift in the management of viral infections, offering a potent means of control and potential cure. In this review, we delve into the cutting-edge progress in RNA-targeting antiviral agents, encompassing antisense oligonucleotides (ASOs), small interfering RNAs (siRNAs), small and bifunctional molecules. We provide an in-depth examination of their strategic molecular design and elucidate the underlying mechanisms of action that confer their antiviral efficacy. By synthesizing recent findings, we shed light on the innovative potential of RNA-targeting approaches and their pivotal role in advancing the frontiers of antiviral drug discovery.<br /> (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1878-5832
Volume :
29
Issue :
8
Database :
MEDLINE
Journal :
Drug discovery today
Publication Type :
Academic Journal
Accession number :
38950729
Full Text :
https://doi.org/10.1016/j.drudis.2024.104074