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Nesfatin-1 ameliorates pathological abnormalities in Drosophila hTau model of Alzheimer's disease.
- Source :
-
Biochemical and biophysical research communications [Biochem Biophys Res Commun] 2024 Oct 01; Vol. 727, pp. 150311. Date of Electronic Publication: 2024 Jun 25. - Publication Year :
- 2024
-
Abstract
- In human Alzheimer's disease (AD), the aggregation of tau protein is considered a significant hallmark, along with amyloid-beta. The formation of neurofibrillary tangles due to aberrant phosphorylation of tau disrupts microtubule stability, leading to neuronal toxicity, dysfunction, and subsequent cell death. Nesfatin-1 is a neuropeptide primarily known for regulating appetite and energy homeostasis. However, the function of Nesfatin-1 in a neuroprotective role has not been investigated. In this study, we aimed to elucidate the effect of Nesfatin-1 on tau pathology using the Drosophila model system. Our findings demonstrate that Nesfatin-1 effectively mitigates the pathological phenotypes observed in Drosophila human Tau overexpression models. Nesfatin-1 overexpression rescued the neurodegenerative phenotypes in the adult fly's eye and bristle. Additionally, Nesfatin-1 improved locomotive behavior, neuromuscular junction formation, and lifespan in the hTau AD model. Moreover, Nesfatin-1 controls tauopathy by reducing the protein level of hTau. Overall, this research highlights the potential therapeutic applications of Nesfatin-1 in ameliorating the pathological features associated with Alzheimer's disease.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 The Authors. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Humans
Drosophila Proteins metabolism
Drosophila Proteins genetics
Drosophila melanogaster metabolism
DNA-Binding Proteins metabolism
DNA-Binding Proteins genetics
Calcium-Binding Proteins metabolism
Calcium-Binding Proteins genetics
Neuromuscular Junction metabolism
Neuromuscular Junction pathology
Animals, Genetically Modified
Drosophila
Locomotion
Longevity
Alzheimer Disease pathology
Alzheimer Disease metabolism
Nucleobindins metabolism
Nucleobindins genetics
tau Proteins metabolism
tau Proteins genetics
Disease Models, Animal
Subjects
Details
- Language :
- English
- ISSN :
- 1090-2104
- Volume :
- 727
- Database :
- MEDLINE
- Journal :
- Biochemical and biophysical research communications
- Publication Type :
- Academic Journal
- Accession number :
- 38950494
- Full Text :
- https://doi.org/10.1016/j.bbrc.2024.150311