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LncRNA PCAT6 promotes the occurrence of laryngeal squamous cell carcinoma via modulation of the miR-4731-5p/NOTCH3 axis.
- Source :
-
Journal of radiation research [J Radiat Res] 2024 Jul 22; Vol. 65 (4), pp. 474-481. - Publication Year :
- 2024
-
Abstract
- Laryngeal squamous cell carcinoma (LSCC) is one of the most aggressive cancers that affect the head and neck region. Recent researches have confirmed that long non-coding RNAs (lncRNAs) present an emerging role in diversiform diseases including cancers. Prostate cancer-associated ncRNA transcript 6 (PCAT6) is an oncogene in lung cancer, cervical cancer, colon cancer and gastric cancer, but its role in LSCC is still unknown. In the current study, we attempted to figure out the role of PCAT6 in LSCC. RT-qPCR was to analyze PCAT6 expression in LSCC cells. Functional assays were to uncover the role of PCAT6 in LSCC. Mechanism assays were to explore the regulatory mechanism behind PCAT6 in LSCC. PCAT6 exhibited higher expression in LSCC cells and PCAT6 strengthened cell proliferation and inhibited cell apoptosis. Furthermore, lncRNA PCAT6 modulated notch receptor 3 expression and activated NOTCH signaling pathway via serving as a sponge for miR-4731-5p. Taken together, lncRNA PCAT6 was identified as an oncogene in LSCC, which revealed that PCAT6 might be used as potential therapeutic target for LSCC.<br /> (© The Author(s) 2024. Published by Oxford University Press on behalf of The Japanese Radiation Research Society and Japanese Society for Radiation Oncology.)
- Subjects :
- Humans
Cell Line, Tumor
Carcinoma, Squamous Cell genetics
Carcinoma, Squamous Cell metabolism
Carcinoma, Squamous Cell pathology
Base Sequence
RNA, Long Noncoding genetics
RNA, Long Noncoding metabolism
Laryngeal Neoplasms genetics
Laryngeal Neoplasms pathology
Laryngeal Neoplasms metabolism
MicroRNAs metabolism
MicroRNAs genetics
Gene Expression Regulation, Neoplastic
Receptor, Notch3 metabolism
Receptor, Notch3 genetics
Cell Proliferation
Apoptosis
Signal Transduction
Subjects
Details
- Language :
- English
- ISSN :
- 1349-9157
- Volume :
- 65
- Issue :
- 4
- Database :
- MEDLINE
- Journal :
- Journal of radiation research
- Publication Type :
- Academic Journal
- Accession number :
- 38950346
- Full Text :
- https://doi.org/10.1093/jrr/rrae042