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Porphyrin-Based Organic Nanoparticles with NIR-IIa Fluorescence for Orthotopic Glioblastoma Theranostics.
- Source :
-
ACS applied materials & interfaces [ACS Appl Mater Interfaces] 2024 Jul 17; Vol. 16 (28), pp. 35925-35935. Date of Electronic Publication: 2024 Jul 01. - Publication Year :
- 2024
-
Abstract
- The development of efficient theranostic nanoagents for the precise diagnosis and targeted therapy of glioblastoma (GBM) remains a big challenge. Herein, we designed and developed porphyrin-based organic nanoparticles (PNP NPs) with strong emission in the near-infrared IIa window (NIR-IIa) for orthotopic GBM theranostics. PNP NPs possess favorable photoacoustic and photothermal properties, high photostability, and low toxicity. After modification with the RGD peptide, the obtained PNPD NPs exhibited enhanced blood-brain barrier (BBB) penetration capability and GBM targeting ability. NIR-IIa imaging was employed to monitor the in vivo biodistribution and accumulation of the nanoparticles, revealing a significant enhancement in penetration depth and signal-to-noise ratio. Both in vitro and in vivo results demonstrated that PNPD NPs effectively inhibited the proliferation of tumor cells and induced negligible side effects in normal brain tissues. In general, the work presented a kind of brain-targeted porphyrin-based NPs with NIR-IIa fluorescence for orthotopic glioblastoma theranostics, showing promising prospects for clinical translation.
- Subjects :
- Animals
Humans
Mice
Brain Neoplasms diagnostic imaging
Brain Neoplasms drug therapy
Brain Neoplasms pathology
Cell Line, Tumor
Infrared Rays
Tissue Distribution
Blood-Brain Barrier metabolism
Mice, Nude
Antineoplastic Agents chemistry
Antineoplastic Agents pharmacology
Cell Proliferation drug effects
Mice, Inbred BALB C
Fluorescence
Glioblastoma diagnostic imaging
Glioblastoma drug therapy
Glioblastoma pathology
Glioblastoma metabolism
Nanoparticles chemistry
Theranostic Nanomedicine
Porphyrins chemistry
Porphyrins pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1944-8252
- Volume :
- 16
- Issue :
- 28
- Database :
- MEDLINE
- Journal :
- ACS applied materials & interfaces
- Publication Type :
- Academic Journal
- Accession number :
- 38950334
- Full Text :
- https://doi.org/10.1021/acsami.4c03012