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Antioxidant, antiglycation, and antibacterial of copper oxide nanoparticles synthesized using Caesalpinia Sappan extract.
- Source :
-
Drug discoveries & therapeutics [Drug Discov Ther] 2024 Jul 09; Vol. 18 (3), pp. 167-177. Date of Electronic Publication: 2024 Jun 28. - Publication Year :
- 2024
-
Abstract
- Synthesis of metal nanoparticles using plant extracts is environmentally friendly and of increasing interest. However, not all plant extracts can meet successfully on the synthesis. Therefore, searching for the high potential extracts that can reduce the metal salt precursor in the synthesis reaction is essential. The present study explores the synthesis of copper oxide nanoparticles (CuONPs) using Caesalpinia sappan heartwood extract. Phytochemical analysis and determination of the total phenolic content of the extract were performed before use as a reducing agent. Under the suitable synthesized condition, a color change in the color of the solutions to brown confirmed the formation of CuONPs. The obtained CuONPs were confirmed using ultraviolet-visible spectroscopy, photon correlation spectroscopy, X-ray diffraction, scanning electron microscope, energy dispersive X-ray, and Fourier transform infrared analysis. The synthesized CuONPs investigated for antioxidant, antiglycation, and antibacterial activities. CuONPs possessed antioxidant activities by quenching free radicals with an IC <subscript>50</subscript> value of 63.35 µg/mL and reducing activity with an EC range of 3.19-10.27 mM/mg. CuONPs also inhibited the formation of advanced glycation end products in the bovine serum albumin/ribose model with an IC <subscript>50</subscript> value of 17.05 µg/mL. In addition, CuONPs showed inhibition of human pathogens, including Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli, and prevention of biofilm formation and biofilm eradication, with maximum inhibition of approx. 75%. Our findings suggest that C. sappan extract can be used to obtain highly bioactive CuONPs for the development of certain medical devices and therapeutic agents.
- Subjects :
- Glycation End Products, Advanced
Staphylococcus aureus drug effects
Microbial Sensitivity Tests
Serum Albumin, Bovine chemistry
Escherichia coli drug effects
Caesalpinia chemistry
Copper chemistry
Copper pharmacology
Plant Extracts pharmacology
Plant Extracts chemistry
Anti-Bacterial Agents pharmacology
Anti-Bacterial Agents chemistry
Antioxidants pharmacology
Antioxidants chemistry
Metal Nanoparticles chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1881-784X
- Volume :
- 18
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- Drug discoveries & therapeutics
- Publication Type :
- Academic Journal
- Accession number :
- 38945877
- Full Text :
- https://doi.org/10.5582/ddt.2024.01030