Back to Search
Start Over
COVID-19 vaccination and major cardiovascular and haematological adverse events in Abu Dhabi: retrospective cohort study.
- Source :
-
Nature communications [Nat Commun] 2024 Jun 28; Vol. 15 (1), pp. 5490. Date of Electronic Publication: 2024 Jun 28. - Publication Year :
- 2024
-
Abstract
- The widespread administration of COVID-19 vaccines has prompted a need to understand their safety profile. This investigation focuses on the safety of inactivated and mRNA-based COVID-19 vaccines, particularly concerning potential cardiovascular and haematological adverse events. A retrospective cohort study was conducted for 1.3 million individuals residing in Abu Dhabi, United Arab Emirates, who received 1.8 million doses of the inactivated BBIBP CorV (by SinoPharm) and mRNA-based BNT162b2 (Pfizer-BioNTech) vaccines between June 1, 2021, and June 30, 2022. The study's primary outcome was to assess the occurrence of selected cardiovascular and haematological events leading to hospitalization or emergency room visits within 21 days post-vaccination. Results showed no significant increase in the incidence rates of these events compared to the subsequent 22 to 42 days following vaccination. Analysis revealed no elevated risk for adverse outcomes following first (IRR 1·03; 95% CI 0·82-1·31), second (IRR 0·92; 95% CI 0·72-1·16) and third (IRR 0·82; 95% CI 0·66-1·00) doses of either vaccine. This study found no substantial link between receiving either mRNA and inactivated COVID-19 vaccines and a higher likelihood of cardiovascular or haematological events within 21 days after vaccination.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Retrospective Studies
United Arab Emirates epidemiology
Male
Female
Middle Aged
Adult
Aged
Young Adult
Hematologic Diseases epidemiology
Adolescent
COVID-19 Vaccines adverse effects
COVID-19 Vaccines immunology
COVID-19 Vaccines administration & dosage
COVID-19 prevention & control
COVID-19 epidemiology
COVID-19 immunology
Cardiovascular Diseases epidemiology
BNT162 Vaccine adverse effects
BNT162 Vaccine immunology
Vaccines, Inactivated adverse effects
Vaccines, Inactivated immunology
Vaccines, Inactivated administration & dosage
SARS-CoV-2 immunology
Vaccination adverse effects
Subjects
Details
- Language :
- English
- ISSN :
- 2041-1723
- Volume :
- 15
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Nature communications
- Publication Type :
- Academic Journal
- Accession number :
- 38944652
- Full Text :
- https://doi.org/10.1038/s41467-024-49744-6