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Cancer-associated fibroblasts promote proliferation, angiogenesis, metastasis and immunosuppression in gastric cancer.
- Source :
-
Matrix biology : journal of the International Society for Matrix Biology [Matrix Biol] 2024 Sep; Vol. 132, pp. 59-71. Date of Electronic Publication: 2024 Jun 25. - Publication Year :
- 2024
-
Abstract
- Despite advances in surgery, radiotherapy and immunotherapy, the mortality rate for gastric cancer remains one of the highest in the world. A large body of evidence has demonstrated that cancer-associated fibroblasts (CAFs), as core members of the stroma, can secrete cytokines, proteins and exosomes to create a tumour microenvironment that is conducive to cancer cell survival. CAFs can also interact with cancer cells to form a complex signalling network, enabling cancer cells to more easily metastasise to other organs and tissues in the body and develop metastatic foci. In this review, we provide an overview of the CAFs concept and activators. We focus on elucidating their effects on immune cells, intratumoural vasculature, extracellular matrix, as well as cancer cell activity, metastatic power and metabolism, and on enhancing the metastatic ability of cancer cells through activation of JAK/STAT, NF/κB and CXCL12/CXCR4. Various therapeutic agents targeting CAFs are also under development and are expected to improve the prognosis of gastric cancer in combination with existing treatment options.<br />Competing Interests: Declaration of Competing Interest All authors declare that they have no competing interests.<br /> (Copyright © 2024. Published by Elsevier B.V.)
- Subjects :
- Animals
Humans
Cell Proliferation
Chemokine CXCL12 metabolism
Chemokine CXCL12 genetics
Neoplasm Metastasis
Cancer-Associated Fibroblasts metabolism
Cancer-Associated Fibroblasts pathology
Neovascularization, Pathologic pathology
Neovascularization, Pathologic metabolism
Signal Transduction
Stomach Neoplasms blood supply
Stomach Neoplasms immunology
Stomach Neoplasms metabolism
Stomach Neoplasms pathology
Tumor Microenvironment
Subjects
Details
- Language :
- English
- ISSN :
- 1569-1802
- Volume :
- 132
- Database :
- MEDLINE
- Journal :
- Matrix biology : journal of the International Society for Matrix Biology
- Publication Type :
- Academic Journal
- Accession number :
- 38936680
- Full Text :
- https://doi.org/10.1016/j.matbio.2024.06.004