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Exploring Neuroimaging Association Scores in adulthood ADHD and middle-age trajectories.

Authors :
Bandeira CE
Grevet EH
Vitola ES
da Silva BS
Cupertino RB
Picon FA
Ito LT
Tavares MEA
Rovaris DL
Grimm O
Bau CHD
Source :
Journal of psychiatric research [J Psychiatr Res] 2024 Aug; Vol. 176, pp. 348-353. Date of Electronic Publication: 2024 Jun 17.
Publication Year :
2024

Abstract

Attention-Deficit/Hyperactivity Disorder (ADHD) is a neurodevelopmental disorder associated with brain differences in children, but not in adults. A combined evaluation of the regional brain differences could improve statistical power and, consequently, allow the detection of possible effects in adults. Thus, our aim is to verify whether Neuroimaging Association Scores (NAS) are associated with adulthood ADHD and clinical trajectories of the disorder in midlife. Clinical and neuroimaging data were collected for 121 subjects with ADHD (mean age: 47.1 ± 10.5; 43% male) and 82 controls (mean age: 38.2 ± 9.0; 54.9% male). Cases were assessed seven and thirteen years after baseline diagnosis, and their clinical trajectories were classified as stable if they fulfilled ADHD diagnosis in all assessments or unstable if they presented remission and recurrence of symptoms. Neuroimaging data were acquired in the last clinical assessment (thirteen years after baseline) and NAS were calculated as a weighted sum of the associations previously reported by meta-analyses for three types of structural brain modalities: cortical thickness, cortical surface area, and subcortical volume. The NAS for cortical surface area was higher in cases compared to controls. No association was found for NAS and number of symptoms of ADHD or clinical trajectories. The fact that differences were restricted to ADHD diagnostic status suggests a susceptibility effect that is not extended to subtle aspects of the disorder. Our results also suggest that evaluating overall effects may have advantages especially when applied to adult ADHD samples.<br />Competing Interests: Declaration of competing interest None.<br /> (Copyright © 2024 Elsevier Ltd. All rights reserved.)

Details

Language :
English
ISSN :
1879-1379
Volume :
176
Database :
MEDLINE
Journal :
Journal of psychiatric research
Publication Type :
Academic Journal
Accession number :
38936238
Full Text :
https://doi.org/10.1016/j.jpsychires.2024.06.025