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Effects of N-Methyl-d-Aspartate Receptor Antagonists on Gamma-Band Activity During Auditory Stimulation Compared With Electro/Magneto-encephalographic Data in Schizophrenia and Early-Stage Psychosis: A Systematic Review and Perspective.
- Source :
-
Schizophrenia bulletin [Schizophr Bull] 2024 Aug 27; Vol. 50 (5), pp. 1104-1116. - Publication Year :
- 2024
-
Abstract
- Background and Hypothesis: N-Methyl-d-aspartate receptor (NMDA-R) hypofunctioning has been hypothesized to be involved in circuit dysfunctions in schizophrenia (ScZ). Yet, it remains to be determined whether the physiological changes observed following NMDA-R antagonist administration are consistent with auditory gamma-band activity in ScZ which is dependent on NMDA-R activity.<br />Study Design: This systematic review investigated the effects of NMDA-R antagonists on auditory gamma-band activity in preclinical (n = 15) and human (n = 3) studies and compared these data to electro/magneto-encephalographic measurements in ScZ patients (n = 37) and 9 studies in early-stage psychosis. The following gamma-band parameters were examined: (1) evoked spectral power, (2) intertrial phase coherence (ITPC), (3) induced spectral power, and (4) baseline power.<br />Study Results: Animal and human pharmacological data reported a reduction, especially for evoked gamma-band power and ITPC, as well as an increase and biphasic effects of gamma-band activity following NMDA-R antagonist administration. In addition, NMDA-R antagonists increased baseline gamma-band activity in preclinical studies. Reductions in ITPC and evoked gamma-band power were broadly compatible with findings observed in ScZ and early-stage psychosis patients where the majority of studies observed decreased gamma-band spectral power and ITPC. In regard to baseline gamma-band power, there were inconsistent findings. Finally, a publication bias was observed in studies investigating auditory gamma-band activity in ScZ patients.<br />Conclusions: Our systematic review indicates that NMDA-R antagonists may partially recreate reductions in gamma-band spectral power and ITPC during auditory stimulation in ScZ. These findings are discussed in the context of current theories involving alteration in E/I balance and the role of NMDA hypofunction in the pathophysiology of ScZ.<br /> (© The Author(s) 2024. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center.)
- Subjects :
- Humans
Magnetoencephalography
Excitatory Amino Acid Antagonists pharmacology
Excitatory Amino Acid Antagonists administration & dosage
Evoked Potentials, Auditory physiology
Evoked Potentials, Auditory drug effects
Acoustic Stimulation
Animals
Schizophrenia physiopathology
Schizophrenia drug therapy
Psychotic Disorders physiopathology
Psychotic Disorders drug therapy
Gamma Rhythm physiology
Gamma Rhythm drug effects
Receptors, N-Methyl-D-Aspartate antagonists & inhibitors
Subjects
Details
- Language :
- English
- ISSN :
- 1745-1701
- Volume :
- 50
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Schizophrenia bulletin
- Publication Type :
- Academic Journal
- Accession number :
- 38934800
- Full Text :
- https://doi.org/10.1093/schbul/sbae090