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Alzheimer's disease biomarker burden in primary motor cortices is associated with poorer dexterity performance.
- Source :
-
Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Aug; Vol. 20 (8), pp. 5792-5799. Date of Electronic Publication: 2024 Jun 27. - Publication Year :
- 2024
-
Abstract
- Introduction: Motor function has correlated with longevity and functionality; however, there is limited research on those with Alzheimer's disease (AD). We studied the association between motor functionality and AD pathology in primary motor and medial temporal cortices.<br />Methods: A total of 206 participants with a clinical diagnosis of cognitively healthy, AD, or mild cognitive impairment (MCI) underwent imaging and motor assessment. Linear regressions and analyses of variance were applied to test the prediction from AD imaging biomarkers to motor performance and the diagnosis group differences in motor performance.<br />Results: Increased neurodegeneration was associated with worsening dexterity and lower walking speed, and increased amyloid and tau were associated with worsening dexterity. AD and MCI participants had lower motor performance than the cognitively healthy participants.<br />Discussion: Increased AD pathology is associated with worsening dexterity performance. The decline in dexterity in those with AD pathology may offer an opportunity for non-pharmacological therapy intervention.<br />Highlights: Noted worsening dexterity performance was associated with greater Alzheimer's disease (AD) pathology (tau, amyloid beta, and neurodegeneration) in primary motor cortices. Similarly, increased neurodegeneration and tau pathology in parahippocampal, hippocampal, and entorhinal cortices is associated with worsening dexterity performance. Motor performance declined in those with clinical and preclinical AD among an array of motor assessments.<br /> (© 2024 The Author(s). Alzheimer's & Dementia published by Wiley Periodicals LLC on behalf of Alzheimer's Association.)
- Subjects :
- Humans
Male
Female
Aged
tau Proteins cerebrospinal fluid
Magnetic Resonance Imaging
Amyloid beta-Peptides metabolism
Aged, 80 and over
Positron-Emission Tomography
Neuropsychological Tests statistics & numerical data
Alzheimer Disease physiopathology
Motor Cortex physiopathology
Motor Cortex diagnostic imaging
Biomarkers
Cognitive Dysfunction physiopathology
Subjects
Details
- Language :
- English
- ISSN :
- 1552-5279
- Volume :
- 20
- Issue :
- 8
- Database :
- MEDLINE
- Journal :
- Alzheimer's & dementia : the journal of the Alzheimer's Association
- Publication Type :
- Academic Journal
- Accession number :
- 38934641
- Full Text :
- https://doi.org/10.1002/alz.13899