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Germ Cell Tumor of the Testis: Lethal Subtypes of a Curable Cancer.
- Source :
-
Journal of clinical medicine [J Clin Med] 2024 Jun 12; Vol. 13 (12). Date of Electronic Publication: 2024 Jun 12. - Publication Year :
- 2024
-
Abstract
- Germ cell tumor of the testis (GCT) is a curable cancer even when it is widely metastatic; however, outcomes can differ based on tumor histology. Chemo-resistance in certain phenotypes, such as teratoma and yolk sac tumor, contributes to poor clinical outcomes in some patients with GCT. Despite this resistance to S-YSTemic therapy, many of these tumor subtypes remain amenable to surgical resection and possible cure. In this study, we report on a series of seven patients highlighting two chemo-resistant subtypes of nonseminomatous germ cell tumor (NSGCT), sarcomatoid yolk sac tumor (S-YST), and epithelioid trophoblastic tumor (ETT) for which early resection rather than additional salvage chemotherapy or high-dose intense chemotherapy might provide a superior clinical outcome and enhance cure rate.
Details
- Language :
- English
- ISSN :
- 2077-0383
- Volume :
- 13
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- Journal of clinical medicine
- Publication Type :
- Academic Journal
- Accession number :
- 38929965
- Full Text :
- https://doi.org/10.3390/jcm13123436