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The Role of the PAX Genes in Renal Cell Carcinoma.
- Source :
-
International journal of molecular sciences [Int J Mol Sci] 2024 Jun 19; Vol. 25 (12). Date of Electronic Publication: 2024 Jun 19. - Publication Year :
- 2024
-
Abstract
- Renal cell carcinoma (RCC) is a significant oncological challenge due to its heterogeneous nature and limited treatment options. The PAX developmental gene family encodes nine highly conserved transcription factors that play crucial roles in embryonic development and organogenesis, which have been implicated in the occurrence and development of RCC. This review explores the molecular landscape of RCC, with a specific focus on the role of the PAX gene family in RCC tumorigenesis and disease progression. Of the various RCC subtypes, clear cell renal cell carcinoma (ccRCC) is the most prevalent, characterized by the loss of the von Hippel-Lindau ( VHL ) tumor suppressor gene. Here, we review the published literature on the expression patterns and functional implications of PAX genes, particularly PAX2 and PAX8 , in the three most common RCC subtypes, including ccRCC, papillary RCC (PRCC), and chromophobe RCC (ChRCC). Further, we review the interactions and potential biological mechanisms involving PAX genes and VHL loss in driving the pathogenesis of RCC, including the key signaling pathways mediated by VHL in ccRCC and associated mechanisms implicating PAX . Lastly, concurrent with our update regarding PAX gene research in RCC, we review and comment on the targeting of PAX towards the development of novel RCC therapies.
- Subjects :
- Humans
Gene Expression Regulation, Neoplastic
PAX2 Transcription Factor genetics
PAX2 Transcription Factor metabolism
Von Hippel-Lindau Tumor Suppressor Protein genetics
Von Hippel-Lindau Tumor Suppressor Protein metabolism
Animals
PAX8 Transcription Factor genetics
PAX8 Transcription Factor metabolism
Signal Transduction genetics
Carcinoma, Renal Cell genetics
Carcinoma, Renal Cell metabolism
Carcinoma, Renal Cell pathology
Kidney Neoplasms genetics
Kidney Neoplasms metabolism
Paired Box Transcription Factors genetics
Paired Box Transcription Factors metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1422-0067
- Volume :
- 25
- Issue :
- 12
- Database :
- MEDLINE
- Journal :
- International journal of molecular sciences
- Publication Type :
- Academic Journal
- Accession number :
- 38928435
- Full Text :
- https://doi.org/10.3390/ijms25126730