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Exploring the translational landscape of the long noncoding RNA transcriptome in acute respiratory distress syndrome: it is a long way to the top.
- Source :
-
European respiratory review : an official journal of the European Respiratory Society [Eur Respir Rev] 2024 Jun 26; Vol. 33 (172). Date of Electronic Publication: 2024 Jun 26 (Print Publication: 2024). - Publication Year :
- 2024
-
Abstract
- Acute respiratory distress syndrome (ARDS) poses a significant and widespread public health challenge. Extensive research conducted in recent decades has considerably improved our understanding of the disease pathophysiology. Nevertheless, ARDS continues to rank among the leading causes of mortality in intensive care units and its management remains a formidable task, primarily due to its remarkable heterogeneity. As a consequence, the syndrome is underdiagnosed, prognostication has important gaps and selection of the appropriate therapeutic approach is laborious. In recent years, the noncoding transcriptome has emerged as a new area of attention for researchers interested in biomarker development. Numerous studies have confirmed the potential of long noncoding RNAs (lncRNAs), transcripts with little or no coding information, as noninvasive tools for diagnosis, prognosis and prediction of the therapeutic response across a broad spectrum of ailments, including respiratory conditions. This article aims to provide a comprehensive overview of lncRNAs with specific emphasis on their role as biomarkers. We review current knowledge on the circulating lncRNAs as potential markers that can be used to enhance decision making in ARDS management. Additionally, we address the primary limitations and outline the steps that will be essential for integration of the use of lncRNAs in clinical laboratories. Our ultimate objective is to provide a framework for the implementation of lncRNAs in the management of ARDS.<br />Competing Interests: Conflict of interest: All authors have nothing to disclose.<br /> (Copyright ©The authors 2024.)
- Subjects :
- Humans
Prognosis
Animals
Genetic Markers
Biomarkers blood
Biomarkers metabolism
Cell-Free Nucleic Acids genetics
Cell-Free Nucleic Acids blood
Gene Expression Profiling
RNA, Long Noncoding genetics
RNA, Long Noncoding metabolism
Respiratory Distress Syndrome genetics
Respiratory Distress Syndrome therapy
Respiratory Distress Syndrome metabolism
Respiratory Distress Syndrome diagnosis
Respiratory Distress Syndrome physiopathology
Transcriptome
Predictive Value of Tests
Subjects
Details
- Language :
- English
- ISSN :
- 1600-0617
- Volume :
- 33
- Issue :
- 172
- Database :
- MEDLINE
- Journal :
- European respiratory review : an official journal of the European Respiratory Society
- Publication Type :
- Academic Journal
- Accession number :
- 38925793
- Full Text :
- https://doi.org/10.1183/16000617.0013-2024