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Dietary protein modulates intestinal dendritic cells to establish mucosal homeostasis.
- Source :
-
Mucosal immunology [Mucosal Immunol] 2024 Oct; Vol. 17 (5), pp. 911-922. Date of Electronic Publication: 2024 Jun 24. - Publication Year :
- 2024
-
Abstract
- Dietary proteins are taken up by intestinal dendritic cells (DCs), cleaved into peptides, loaded to major histocompatibility complexes, and presented to T cells to generate an immune response. Amino acid (AA)-diets do not have the same effects because AAs cannot bind to major histocompatibility complex to activate T cells. Here, we show that impairment in regulatory T cell generation and loss of tolerance in mice fed a diet lacking whole protein is associated with major transcriptional changes in intestinal DCs including downregulation of genes related to DC maturation, activation and decreased gene expression of immune checkpoint molecules. Moreover, the AA-diet had a profound effect on microbiome composition, including an increase in Akkermansia muciniphilia and Oscillibacter and a decrease in Lactococcus lactis and Bifidobacterium. Although microbiome transfer experiments showed that AA-driven microbiome modulates intestinal DC gene expression, most of the unique transcriptional change in DC was linked to the absence of whole protein in the diet. Our findings highlight the importance of dietary proteins for intestinal DC function and mucosal tolerance.<br /> (Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Mice
Immune Tolerance
T-Lymphocytes, Regulatory immunology
Mice, Inbred C57BL
Gene Expression Regulation
Immunity, Mucosal
Dendritic Cells immunology
Dendritic Cells metabolism
Dietary Proteins
Homeostasis
Gastrointestinal Microbiome immunology
Intestinal Mucosa immunology
Intestinal Mucosa metabolism
Subjects
Details
- Language :
- English
- ISSN :
- 1935-3456
- Volume :
- 17
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Mucosal immunology
- Publication Type :
- Academic Journal
- Accession number :
- 38925529
- Full Text :
- https://doi.org/10.1016/j.mucimm.2024.06.006