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Mapping Motor Cortical Network Excitability and Connectivity Changes in De Novo Parkinson's Disease.
- Source :
-
Movement disorders : official journal of the Movement Disorder Society [Mov Disord] 2024 Sep; Vol. 39 (9), pp. 1523-1532. Date of Electronic Publication: 2024 Jun 24. - Publication Year :
- 2024
-
Abstract
- Background: Transcranial magnetic stimulation-electroencephalography (TMS-EEG) has demonstrated decreased excitability in the primary motor cortex (M1) and increased excitability in the pre-supplementary motor area (pre-SMA) in moderate-advanced Parkinson's disease (PD).<br />Objectives: The aim was to investigate whether these abnormalities are evident from the early stages of the disease, their behavioral correlates, and relationship to cortico-subcortical connections.<br />Methods: Twenty-eight early, drug-naive (de novo) PD patients and 28 healthy controls (HCs) underwent TMS-EEG to record TMS-evoked potentials (TEPs) from the primary motor cortex (M1) and the pre-SMA, kinematic recording of finger-tapping movements, and a 3T-MRI (magnetic resonance imaging) scan to obtain diffusion tensor imaging (DTI) reconstruction of white matter (WM) tracts connecting M1 to the ventral lateral anterior thalamic nucleus and pre-SMA to the anterior putamen.<br />Results: We found reduced M1 TEP P30 amplitude in de novo PD patients compared to HCs and similar pre-SMA TEP N40 amplitude between groups. PD patients exhibited smaller amplitude and slower velocity in finger-tapping movements and altered structural integrity in WM tracts of interest, although these changes did not correlate with TEPs.<br />Conclusions: M1 hypoexcitability is a characteristic of PD from early phases and may be a marker of the parkinsonian state. Pre-SMA hyperexcitability is not evident in early PD and possibly emerges at later stages of the disease. © 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.<br /> (© 2024 The Author(s). Movement Disorders published by Wiley Periodicals LLC on behalf of International Parkinson and Movement Disorder Society.)
- Subjects :
- Humans
Male
Female
Middle Aged
Aged
Magnetic Resonance Imaging
Nerve Net physiopathology
Nerve Net diagnostic imaging
Diffusion Tensor Imaging
Neural Pathways physiopathology
Neural Pathways diagnostic imaging
Brain Mapping
Parkinson Disease physiopathology
Parkinson Disease diagnostic imaging
Motor Cortex physiopathology
Motor Cortex diagnostic imaging
Transcranial Magnetic Stimulation methods
Evoked Potentials, Motor physiology
Electroencephalography methods
Subjects
Details
- Language :
- English
- ISSN :
- 1531-8257
- Volume :
- 39
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Movement disorders : official journal of the Movement Disorder Society
- Publication Type :
- Academic Journal
- Accession number :
- 38924157
- Full Text :
- https://doi.org/10.1002/mds.29901