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Monitoring Influenza C and D Viruses in Patients With Respiratory Diseases in Japan, January 2018 to March 2023.
- Source :
-
Influenza and other respiratory viruses [Influenza Other Respir Viruses] 2024 Jun; Vol. 18 (6), pp. e13345. - Publication Year :
- 2024
-
Abstract
- Background: Influenza viruses can cause zoonotic infections that pose public health risks. Surveillance of influenza A and B viruses is conducted globally; however, information on influenza C and D viruses is limited. Longitudinal monitoring of influenza C virus in humans has been conducted in several countries, but there has been no long-term monitoring of influenza D virus in humans. The public health risks associated with the influenza D virus therefore remain unknown.<br />Methods: We established a duplex real-time RT-PCR to detect influenza C and D viruses and analyzed respiratory specimens collected from 2144 patients in Japan with respiratory diseases between January 2018 and March 2023. We isolated viruses and conducted hemagglutination inhibition tests to examine antigenicity and focus reduction assays to determine susceptibility to the cap-dependent endonuclease inhibitor baloxavir marboxil.<br />Results: We detected three influenza C viruses belonging to the C/Kanagawa- or C/Sao Paulo-lineages, which recently circulated globally. None of the specimens was positive for the influenza D virus. The C/Yokohama/1/2022 strain, isolated from the specimen with the highest viral RNA load and belonging to the C/Kanagawa-lineage, showed similar antigenicity to the reference C/Kanagawa-lineage strain and was susceptible to baloxavir.<br />Conclusions: Our duplex real-time RT-PCR is useful for the simultaneous detection of influenza C and D viruses from the same specimen. Adding the influenza D virus to the monitoring of the influenza C virus would help in assessing the public health risks posed by this virus.<br /> (© 2024 The Authors. Influenza and Other Respiratory Viruses published by John Wiley & Sons Ltd.)
- Subjects :
- Humans
Japan epidemiology
Male
Female
Middle Aged
Adult
Aged
Antiviral Agents therapeutic use
Antiviral Agents pharmacology
Morpholines
Hemagglutination Inhibition Tests
Child, Preschool
Child
Adolescent
Young Adult
Thogotovirus genetics
Thogotovirus isolation & purification
Thogotovirus classification
Real-Time Polymerase Chain Reaction
Infant
Aged, 80 and over
Influenza, Human virology
Influenza, Human epidemiology
Triazines pharmacology
Gammainfluenzavirus isolation & purification
Gammainfluenzavirus genetics
Pyridones
Dibenzothiepins
Subjects
Details
- Language :
- English
- ISSN :
- 1750-2659
- Volume :
- 18
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Influenza and other respiratory viruses
- Publication Type :
- Academic Journal
- Accession number :
- 38923307
- Full Text :
- https://doi.org/10.1111/irv.13345