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Prevalence and clinical implications of bloodstream infections in intensive care patients with or without burn injury: a retrospective cohort study.
- Source :
-
European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology [Eur J Clin Microbiol Infect Dis] 2024 Sep; Vol. 43 (9), pp. 1731-1740. Date of Electronic Publication: 2024 Jun 26. - Publication Year :
- 2024
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Abstract
- Purpose: Severe burn injuries are often accompanied by infections and associated with high morbidity and mortality. This study aimed to compare the prevalence and clinical impact of bacteremia between patients receiving intensive care with and without burns.<br />Methods: This single-center retrospective cohort study at the University Hospital Vienna, Austria, analyzed blood cultures from intensive care unit (ICU) patients with and without burns (2012-2022) to assess the prevalence of bacteremia, the associated pathogen distribution and the 60-day all-cause mortality.<br />Results: In 1170 ICU patients, 303 with burns and 867 without, the prevalence of bacteremia was similar among patients with at least one blood culture (31/157 [19.7%] versus 44/213 [20.7%], OR [95%CI] = 0.95 [0.57-1.57]). Burn patients exhibited a significantly higher frequency of microbiological sampling (51.5% versus 24.5%, p < 0.001), resulting in a higher overall prevalence of bacteremia (10.2% versus 5.1%, p = 0.002). 16.2% of all identified pathogens were multidrug-resistant (MDR). The 60-day all-cause mortality was higher in patients with MDR pathogens than in patients without bacteremia (41.7% versus 10.6%, p = 0.026).<br />Conclusion: Bacteremia prevalence was similar in burn and non-burn patients, with high rates of multidrug-resistant Gram-negative pathogens. The 60-day all-cause mortality was significantly higher in patients with MDR pathogens than in patients without bacteremia.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Retrospective Studies
Male
Female
Middle Aged
Prevalence
Aged
Austria epidemiology
Adult
Drug Resistance, Multiple, Bacterial
Critical Care statistics & numerical data
Anti-Bacterial Agents therapeutic use
Burns complications
Burns microbiology
Burns epidemiology
Burns mortality
Bacteremia epidemiology
Bacteremia microbiology
Bacteremia mortality
Intensive Care Units statistics & numerical data
Subjects
Details
- Language :
- English
- ISSN :
- 1435-4373
- Volume :
- 43
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology
- Publication Type :
- Academic Journal
- Accession number :
- 38922377
- Full Text :
- https://doi.org/10.1007/s10096-024-04877-w