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Genomics- and Transcriptomics-Guided Discovery of Clavatols from Arctic Fungi Penicillium sp. MYA5.
- Source :
-
Marine drugs [Mar Drugs] 2024 May 22; Vol. 22 (6). Date of Electronic Publication: 2024 May 22. - Publication Year :
- 2024
-
Abstract
- Clavatols exhibit a wide range of biological activities due to their diverse structures. A genome mining strategy identified an A5cla cluster from Penicillium sp. MYA5, derived from the Arctic plant Dryas octopetala , is responsible for clavatol biosynthesis. Seven clavatols, including one new clavatol derivate named penicophenone F ( 1 ) and six known clavatols ( 2 - 7 ), were isolated from Penicillium sp. MYA5 using a transcriptome mining strategy. These structures were elucidated by comprehensive spectroscopic analysis. Antibacterial, aldose reductase inhibition, and siderophore-producing ability assays were conducted on compounds 1 - 7 . Compounds 1 and 2 demonstrated inhibitory effects on the ALR2 enzyme with inhibition rates of 75.3% and 71.6% at a concentration of 10 μM, respectively. Compound 6 exhibited antibacterial activity against Staphylococcus aureus and Escherichia coli with MIC values of 4.0 μg/mL and 4.0 μg/mL, respectively. Additionally, compounds 1 , 5 , and 6 also showed potential iron-binding ability.
- Subjects :
- Genomics methods
Escherichia coli drug effects
Escherichia coli genetics
Microbial Sensitivity Tests
Transcriptome
Arctic Regions
Siderophores pharmacology
Aldehyde Reductase antagonists & inhibitors
Aldehyde Reductase genetics
Penicillium genetics
Anti-Bacterial Agents pharmacology
Anti-Bacterial Agents chemistry
Staphylococcus aureus drug effects
Subjects
Details
- Language :
- English
- ISSN :
- 1660-3397
- Volume :
- 22
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Marine drugs
- Publication Type :
- Academic Journal
- Accession number :
- 38921547
- Full Text :
- https://doi.org/10.3390/md22060236