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Simultaneous electrochemical determination of uric acid and hypoxanthine at a TiO 2 /graphene quantum dot-modified electrode.
- Source :
-
Beilstein journal of nanotechnology [Beilstein J Nanotechnol] 2024 Jun 20; Vol. 15, pp. 719-732. Date of Electronic Publication: 2024 Jun 20 (Print Publication: 2024). - Publication Year :
- 2024
-
Abstract
- A TiO <subscript>2</subscript> /graphene quantum dots composite (TiO <subscript>2</subscript> /GQDs) obtained by in situ synthesis of GQDs, derived from coffee grounds, and peroxo titanium complexes was used as electrode modifier in the simultaneous electrochemical determination of uric acid and hypoxanthine. The TiO <subscript>2</subscript> /GQDs material was characterized by photoluminescence, X-ray diffraction, Raman spectroscopy, high-resolution transmission electron microscopy, and energy-dispersive X-ray mapping. The TiO <subscript>2</subscript> /GQDs-GCE exhibits better electrochemical activity for uric acid and hypoxanthine than GQDs/GCE or TiO <subscript>2</subscript> /GCE in differential pulse voltammetry (DPV) measurements. Under optimized conditions, the calibration plots were linear in the range from 1.00 to 15.26 μM for both uric acid and hypoxanthine. The limits of detection of this method were 0.58 and 0.68 μM for uric acid and hypoxanthine, respectively. The proposed DPV method was employed to determine uric acid and hypoxanthine in urine samples with acceptable recovery rates.<br />Competing Interests: The authors have no relevant financial or non-financial interests to disclose.<br /> (Copyright © 2024, Ngoc Hoang et al.)
Details
- Language :
- English
- ISSN :
- 2190-4286
- Volume :
- 15
- Database :
- MEDLINE
- Journal :
- Beilstein journal of nanotechnology
- Publication Type :
- Academic Journal
- Accession number :
- 38919168
- Full Text :
- https://doi.org/10.3762/bjnano.15.60