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Neuroinflammation and acetylcholinesterase inhibition potentials of acyclic monoterpenoids isolated from Cymbopogon distans (Nees ex Steud.) Will. Watson.

Authors :
Singh S
Bhatt D
Singh MK
Mishra S
Shankar U
Maurya A
Padalia RC
Tandon S
Bawankule DU
Verma RS
Source :
Natural product research [Nat Prod Res] 2024 Jun 25, pp. 1-5. Date of Electronic Publication: 2024 Jun 25.
Publication Year :
2024
Publisher :
Ahead of Print

Abstract

Cymbopogon distans (Nees ex Steud.) Will. Watson (Poaceae) is a promising aromatic plant distributed in the Himalayas. In this study, five acyclic monoterpenoids, namely geranyl acetate (RS1), neral (RS2), geranial (RS3), citral (RS4) and geraniol (RS5) were isolated from the essential oil of C. distans . The isolated compounds were tested for in-vitro neuroinflammation inhibitory potential in LPS-stimulated BV2 microglial cells. RS1-RS4 exhibited significant neuroinflammation inhibition without any cytotoxic effect at the dose of 10 μM. RS4, the most active anti-neuroinflammatory compound (TNF-α 31.48 ± 1.00%; IL-6 24.02 ± 0.63%; IL-1β 42.15 ± 1.76%) was also able to inhibit acetylcholinesterase (AChE) in a dose-dependent manner. The results showed that RS4 (an isomeric mixture of neral and geranial) has the potential to inhibit neuroinflammation and AChE, which are the biomarkers of neurodegenerative disorders.

Details

Language :
English
ISSN :
1478-6427
Database :
MEDLINE
Journal :
Natural product research
Publication Type :
Academic Journal
Accession number :
38919044
Full Text :
https://doi.org/10.1080/14786419.2024.2369918