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Mixed-Micelle in Situ Gel as a Candidate for Oral Inflammatory Ulcerative Diseases.
- Source :
-
AAPS PharmSciTech [AAPS PharmSciTech] 2024 Jun 25; Vol. 25 (6), pp. 144. Date of Electronic Publication: 2024 Jun 25. - Publication Year :
- 2024
-
Abstract
- The current treatment for oral inflammatory ulcerative diseases has limitations. In situ forming hydrogels have shown great potential to deliver therapeutic substances for drug delivery to the buccal cavity. This study aimed to prepare and characterize lipid- and surfactant-based mixed micelle in situ gel (MIG) and evaluate whether it can offer more favorable properties than the in situ gel for effective treatment of the disease. Dexamethasone was incorporated into the MIGs particles, based on Poloxamer 407 and chitosan. The lower gelation time at 37 ℃ was considered a criterion to select superior formulations among the different lipid- and surfactant-based candidates. Further characterization was performed to evaluate the opted formulations regarding morphology, physical stability, rheology, texture, and release profile. All formulations were thermoresponsive and had a shorter gelation time as the temperature increased. Dexamethasone was released in a highly controlled manner, and morphological evaluation revealed that the mixed micelle in situ gels had spherical nanoparticles. Thixotropic behavior was observed in all MIGs, indicating a prolonged retention time of the formulation after oral administration. This study has shown that among different MIGs, the one with oleic acid is a more promising candidate than the in situ gel and other MIGs for drug delivery to the buccal cavity.<br /> (© 2024. The Author(s), under exclusive licence to American Association of Pharmaceutical Scientists.)
- Subjects :
- Surface-Active Agents chemistry
Chemistry, Pharmaceutical methods
Hydrogels chemistry
Anti-Inflammatory Agents administration & dosage
Anti-Inflammatory Agents chemistry
Nanoparticles chemistry
Drug Carriers chemistry
Rheology methods
Oral Ulcer drug therapy
Administration, Oral
Lipids chemistry
Oleic Acid chemistry
Micelles
Dexamethasone administration & dosage
Dexamethasone chemistry
Chitosan chemistry
Gels chemistry
Drug Delivery Systems methods
Poloxamer chemistry
Drug Liberation
Subjects
Details
- Language :
- English
- ISSN :
- 1530-9932
- Volume :
- 25
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- AAPS PharmSciTech
- Publication Type :
- Academic Journal
- Accession number :
- 38918282
- Full Text :
- https://doi.org/10.1208/s12249-024-02862-2