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A Triterpene-Based bioactive drug delivery system for combined chemotherapy of liver cancer.
- Source :
-
European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V [Eur J Pharm Biopharm] 2024 Aug; Vol. 201, pp. 114378. Date of Electronic Publication: 2024 Jun 23. - Publication Year :
- 2024
-
Abstract
- Carrier materials always account for the majority particularly in nanosized formulations, which are administrated along with the active ingredient part might result in metabolism related toxicity. The usage of bioactive excipients could not only reduce the sided effect but also provide additional therapeutic effects. In the present study, a triterpene based micellar drug delivery system was developed using a bioactive solanesol derivative. Solanesylamine was prepared firstly followed by conjugating with poly (ethylene glycol) using maleic acid amide linkage. The amphiphilic drug carrier PEGylated (2-propyl-3-methylmaleic acid)-block-solanesol amine (mPEG-CDM-NH-SOL) could be formed into micelles and loaded with doxorubicin (DOX) inside. The micelles were about 112 nm in size and the drug loading content was about 5.97 wt%. An acid triggered drug release behavior was obviously observed for the DOX loaded pH-sensitive micelle mPEG-CDM-NH-SOL-DOX. While not for DOX-loaded micelles without pH-sensitivity (mPEG-NHS-NH-SOL). CCK8 assay showed that the micelles of PEGylated solanesylamines exhibited certain inhibitory effect on tumor cells at high concentration and the pH sensitive ones seemed more toxic. In vivo studies showed that the pH sensitive mPEG-CDM-NH-SOL-DOX had a superior anti-tumor effect, indicating its great potential in cancer treatment.<br />Competing Interests: Declaration of Competing Interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Humans
Mice
Drug Liberation
Hep G2 Cells
Male
Mice, Nude
Mice, Inbred BALB C
Hydrogen-Ion Concentration
Cell Line, Tumor
Antineoplastic Combined Chemotherapy Protocols administration & dosage
Antineoplastic Combined Chemotherapy Protocols pharmacology
Xenograft Model Antitumor Assays
Terpenes
Doxorubicin administration & dosage
Doxorubicin pharmacology
Micelles
Triterpenes administration & dosage
Triterpenes chemistry
Triterpenes pharmacology
Liver Neoplasms drug therapy
Drug Carriers chemistry
Drug Delivery Systems methods
Polyethylene Glycols chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3441
- Volume :
- 201
- Database :
- MEDLINE
- Journal :
- European journal of pharmaceutics and biopharmaceutics : official journal of Arbeitsgemeinschaft fur Pharmazeutische Verfahrenstechnik e.V
- Publication Type :
- Academic Journal
- Accession number :
- 38917949
- Full Text :
- https://doi.org/10.1016/j.ejpb.2024.114378