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Positive effects of extracellular polysaccharides from Paecilomyces hepiali on immune-enhancing properties by regulating gut microbiota in cyclophosphamide-induced mice.
- Source :
-
International journal of biological macromolecules [Int J Biol Macromol] 2024 Aug; Vol. 274 (Pt 2), pp. 133390. Date of Electronic Publication: 2024 Jun 23. - Publication Year :
- 2024
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Abstract
- Paecilomyces hepiali is a precious health-care edible medicinal fungus with rich polysaccharides and exhibits various biological activities. Polysaccharides from P. hepiali fermentation broth (PHP) exhibits good immunomodulatory activity; however, the mechanism underlying PHP-mediated regulation of immunity and gut microbiota remains unclear. To reveal the mechanisms, PHP of different doses were used to intervene cyclophosphamide (CTX)-induced immunosuppressive model mice. The results revealed that PHP facilitated the secretion of serum cytokines, increased the mRNA and protein expression of TLR4/NF-κB signaling pathway. Furthermore, it improved the physical barrier function of the intestine by upregulating the expression of tight junction proteins. PHP increased the proliferation of beneficial bacteria, including, Actinobacteriota, Alistipes, Candidatus&#95;Saccharimonas and unclassified&#95;Clostridia&#95;vadinBB60&#95;group, and reduced the abundance of Proteobacteria, Deferribacterota, Mucispirillum and Escherichia&#95;Shigella, promoted the production of short-chain fatty acids, which were positively associated with immune traits. Thus, as an immune enhancer, PHP has the potential to regulate the intestinal immune response in immunosuppressed mice through modulating gut microbiota.<br />Competing Interests: Declaration of competing interest We declare that we have no financial and personal relationships with other people or organizations that can inappropriately influence our work. There is no professional or other personal interest of any nature or kind in any product, service and/or company that could be construed as influencing the position presented in, or the review of Immune-enhancing effects of extracellular polysaccharides from Paecilomyces hepiali by regulating gut microbiota in cyclophosphamide-induced mice.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Mice
Cytokines metabolism
Male
NF-kappa B metabolism
Toll-Like Receptor 4 metabolism
Toll-Like Receptor 4 genetics
Signal Transduction drug effects
Polysaccharides pharmacology
Cyclophosphamide pharmacology
Gastrointestinal Microbiome drug effects
Paecilomyces chemistry
Fungal Polysaccharides pharmacology
Subjects
Details
- Language :
- English
- ISSN :
- 1879-0003
- Volume :
- 274
- Issue :
- Pt 2
- Database :
- MEDLINE
- Journal :
- International journal of biological macromolecules
- Publication Type :
- Academic Journal
- Accession number :
- 38917915
- Full Text :
- https://doi.org/10.1016/j.ijbiomac.2024.133390