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A novel antibiotic: the antimicrobial effects of CFBSA and its application on electronspun wound dressing.
- Source :
-
Biomedical materials (Bristol, England) [Biomed Mater] 2024 Jul 08; Vol. 19 (5). Date of Electronic Publication: 2024 Jul 08. - Publication Year :
- 2024
-
Abstract
- N-chloro-N-fluorobenzenesulfonylamide (CFBSA), was a novel chlorinating reagent, which exhibits potential antibacterial activities. In this study, CFBSA was confirmed as a wide-broad antimicrobial and bactericidal drug against different gram-negative bacteria, gram-positive bacteria and fungi, while it was found to have low cytotoxicity for eukaryotic cells. In addition, microorganism morphology assay and oxidative stress test was used to determine the antimicrobial mechanisms of CFBSA. According to the results, CFBSA probably had a target on cell membrane and killed microorganism by disrupting its cell membrane. Then, CFBSA was first combined with poly(L-lactide-co-caprolactone) (PLCL)/SF via electrospinning and applied in wound dressings. The characterization of different PLCL/SF of CFBSA-loaded nanofibrous mats was investigated by SEM, water contact angle, Fourier transform infrared spectroscopy, cell compatibility and antimicrobial test. CFBSA-loaded PLCL/SF nanofibrous mats showed excellent antimicrobial activities. In order to balance of the biocompatibility and antibacterial efficiency, SP-2.5 was selected as the ideal loading concentration for further application of CFBSA-loaded PLCL/SF. In conclusion, the electrospun CFBSA-loaded PLCL/SF nanofibrous mat with its broad-spectrum antimicrobial and bactericidal activity and good biocompatibility showed enormous potential for wound dressing.<br /> (© 2024 IOP Publishing Ltd.)
- Subjects :
- Microbial Sensitivity Tests
Biocompatible Materials chemistry
Biocompatible Materials pharmacology
Wound Healing drug effects
Spectroscopy, Fourier Transform Infrared
Gram-Negative Bacteria drug effects
Humans
Materials Testing
Animals
Gram-Positive Bacteria drug effects
Polyesters chemistry
Polyesters pharmacology
Anti-Infective Agents pharmacology
Anti-Infective Agents chemistry
Oxidative Stress drug effects
Bandages
Anti-Bacterial Agents pharmacology
Anti-Bacterial Agents chemistry
Nanofibers chemistry
Subjects
Details
- Language :
- English
- ISSN :
- 1748-605X
- Volume :
- 19
- Issue :
- 5
- Database :
- MEDLINE
- Journal :
- Biomedical materials (Bristol, England)
- Publication Type :
- Academic Journal
- Accession number :
- 38917818
- Full Text :
- https://doi.org/10.1088/1748-605X/ad5ba4