Tweaking synaptic plasticity: Deciphering the role of WWC1 in memory opens new therapeutic horizons.

Authors :: Papassotiropoulos A
de Quervain DJ
Source :: Science signaling [Sci Signal] 2024 Jun 25; Vol. 17 (842), pp. eadp5354. Date of Electronic Publication: 2024 Jun 25.
Publication Year :: 2024
Abstract: WWC1 is a scaffolding protein in the evolutionarily conserved Hippo signaling network and is genetically linked to human memory and synaptic plasticity. In the archives of Science Signaling , Stepan et al. demonstrate the translational potential of modulating WWC1 through pharmacological inhibition of Hippo-pathway kinases to enhance cognition.

Subjects :: Humans
Intracellular Signaling Peptides and Proteins metabolism
Intracellular Signaling Peptides and Proteins genetics
Animals
Protein Serine-Threonine Kinases metabolism
Protein Serine-Threonine Kinases genetics
Proteins metabolism
Proteins genetics
Neuronal Plasticity physiology
Memory physiology
Signal Transduction

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