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The Unusual Adverse Effects of Antituberculosis Therapy in Kidney Patients.
- Source :
-
International journal of mycobacteriology [Int J Mycobacteriol] 2024 Apr 01; Vol. 13 (2), pp. 183-190. Date of Electronic Publication: 2024 Jun 15. - Publication Year :
- 2024
-
Abstract
- Background: Chronic kidney disease (CKD) patients are at a high risk of tuberculosis (TB), with a relative risk of developing active TB of 10%-25%. Similarly, glomerular disease increases the risk of TB due to diminished glomerular filtration rate, proteinuria, and immunosuppression use. Further, the first-line anti-TB drugs are associated with acute kidney injury (AKI) even in patients with normal kidney functions.<br />Methods: We retrospectively identified 10 patients hospitalized with unusual adverse effects of antituberculosis therapy (ATT) from 2013 to 2022.<br />Results: We found three cases of AKI caused by rifampicin: acute interstitial nephritis, crescentic glomerulonephritis, and heme pigment-induced acute tubular necrosis. We observed rifampicin-induced accelerated hypertension and thrombocytopenia in two patients on maintenance hemodialysis. Isoniazid caused pancreatitis and cerebellitis in two CKD patients, respectively. In a CKD patient, we detected acute gout secondary to pyrazinamide-induced reduced uric acid excretion. We also observed cases of drug rash with eosinophilia and systemic symptoms and hypercalcemia due to immune reconstitution inflammatory syndrome in patients with glomerular disease on ATT. Immediate discontinuation of the offending drug, along with specific and supportive management, led to a recovery in all cases.<br />Conclusion: The adverse effects of ATT may be unusually severe and varied in kidney patients due to decreased renal elimination. Early recognition of these adverse effects and timely discontinuation of the offending drug is essential to limit morbidity and mortality.<br /> (Copyright © 2024 Copyright: © 2024 International Journal of Mycobacteriology.)
- Subjects :
- Adult
Aged
Female
Humans
Male
Middle Aged
Glomerulonephritis chemically induced
Immune Reconstitution Inflammatory Syndrome
Isoniazid adverse effects
Isoniazid therapeutic use
Nephritis, Interstitial chemically induced
Pyrazinamide adverse effects
Pyrazinamide therapeutic use
Retrospective Studies
Rifampin adverse effects
Rifampin therapeutic use
Tuberculosis drug therapy
Tuberculosis complications
Acute Kidney Injury chemically induced
Antitubercular Agents adverse effects
Antitubercular Agents therapeutic use
Renal Insufficiency, Chronic complications
Subjects
Details
- Language :
- English
- ISSN :
- 2212-554X
- Volume :
- 13
- Issue :
- 2
- Database :
- MEDLINE
- Journal :
- International journal of mycobacteriology
- Publication Type :
- Academic Journal
- Accession number :
- 38916390
- Full Text :
- https://doi.org/10.4103/ijmy.ijmy_33_24