Recompensation in MASLD-related cirrhosis via metabolic bariatric surgery.

Authors :: Feng G
Han Y
Yang W
Shikora S
Mahawar K
Cheung TT
Targher G
Byrne CD
Hernandez-Gea V
Tilg H
Zheng MH
Source :: Trends in endocrinology and metabolism: TEM [Trends Endocrinol Metab] 2024 Jun 21. Date of Electronic Publication: 2024 Jun 21.
Publication Year :: 2024
Publisher :: Ahead of Print
Abstract: The prognosis of patients with decompensated cirrhosis is poor, with significantly increased liver-related mortality rates. With the rising tide of decompensated cirrhosis associated with metabolic dysfunction-associated steatotic liver disease (MASLD), the role of metabolic bariatric surgery (MBS) in achieving hepatic recompensation is garnering increasing attention. However, the complexity of preoperative assessment, the risk of postoperative disease recurrence, and the potential for patients to experience surgical complications of the MBS present challenges. In this opinion article we analyze the potential of MBS to induce recompensation in MASLD-related cirrhosis, discuss the mechanisms by which MBS may affect recompensation, and compare the characteristics of different MBS procedures; we highlight the therapeutic potential of MBS in MASLD-related cirrhosis recompensation and advocate for research in this complex area.<br />Competing Interests: Declaration of interests V.H-G. reports honoraria for lectures from GORE and Cook Medical. The other authors declare no competing interests.<br /> (Copyright © 2024 Elsevier Ltd. All rights reserved.)