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Quantitative 2-Dimensionsal Digital Subtraction Venography for Venous Interventions: Validation in Phantom and In Vivo Porcine Models.
- Source :
-
Journal of vascular and interventional radiology : JVIR [J Vasc Interv Radiol] 2024 Sep; Vol. 35 (9), pp. 1367-1376.e2. Date of Electronic Publication: 2024 Jun 19. - Publication Year :
- 2024
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Abstract
- Purpose: To determine the feasibility of using a 2-dimensional quantitative digital subtraction venography (qDSV) technique that employs a temporally modulated contrast medium injection to quantify blood velocity in phantom, normal, and stenotic porcine iliac vein models.<br />Materials and Methods: Blood velocity was calculated using qDSV following temporally modulated pulsed injections of iodinated contrast medium and compared with Doppler ultrasound (US) measurements (phantom, in-line sensor; in vivo, diagnostic linear probe). Phantom evaluation was performed in a compliant polyethylene tube phantom with simulated venous flow. In vivo evaluation of qDSV was performed in normal (n = 7) and stenotic (n = 3) iliac vein models. Stenoses were created using endovenous radiofrequency ablation, and blood velocities were determined at baseline, after stenosis, after venoplasty, and after stent placement.<br />Results: In the phantom model, qDSV-calculated blood velocities (12-50 cm/s) had very strong correlations with US-measured velocities (13-51 cm/s) across a range of baseline blood velocities and injection protocols (slope, 1.01-1.13; R <superscript>2</superscript>  = 0.96-0.99). qDSV velocities were similar to US velocities regardless of injection method: (a) custom injector, (b) commercial injector, or (c) hand injection. In the normal in vivo model, qDSV-calculated velocities (5-18 cm/s) had strong correlation (slope, 1.22; R <superscript>2</superscript>  = 0.90) with US-measured velocities (3-20 cm/s). In the stenosis model, blood velocities at baseline, after stenosis, after venoplasty, and after stent placement were similar on qDSV and US at all time points.<br />Conclusions: Venous blood velocity was accurately quantified in a venous phantom and in vivo porcine models using qDSV. Intraprocedural changes in porcine iliac vein blood velocity were quantified with qDSV after creation of a stenosis and subsequently treating it with venoplasty and stent placement.<br /> (Copyright © 2024 SIR. Published by Elsevier Inc. All rights reserved.)
- Subjects :
- Animals
Blood Flow Velocity
Swine
Constriction, Pathologic
Contrast Media administration & dosage
Disease Models, Animal
Reproducibility of Results
Stents
Predictive Value of Tests
Ultrasonography, Doppler
Phlebography
Phantoms, Imaging
Angiography, Digital Subtraction
Iliac Vein diagnostic imaging
Iliac Vein physiopathology
Feasibility Studies
Subjects
Details
- Language :
- English
- ISSN :
- 1535-7732
- Volume :
- 35
- Issue :
- 9
- Database :
- MEDLINE
- Journal :
- Journal of vascular and interventional radiology : JVIR
- Publication Type :
- Academic Journal
- Accession number :
- 38906246
- Full Text :
- https://doi.org/10.1016/j.jvir.2024.06.008