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A critical role for palmitoylation in pyroptosis.

Authors :
Sun Z
Hornung V
Source :
Molecular cell [Mol Cell] 2024 Jun 20; Vol. 84 (12), pp. 2218-2220.
Publication Year :
2024

Abstract

Three recent publications by Du et al., <superscript>1</superscript> Balasubramanian et al., <superscript>2</superscript> and Zhang et al. <superscript>3</superscript> identified palmitoylation on cysteine 191/192 in gasdermin D as a key determinant of gasdermin D membrane translocation and oligomerization, ensuring efficient plasma membrane permeabilization during pyroptosis.<br />Competing Interests: Declaration of interests The authors declare no competing interests.<br /> (Copyright © 2024 Elsevier Inc. All rights reserved.)

Subjects

Subjects :
Humans
Animals
Intracellular Signaling Peptides and Proteins metabolism
Intracellular Signaling Peptides and Proteins genetics
Cell Membrane metabolism
Cysteine metabolism
Protein Transport
Gasdermins
Pyroptosis
Lipoylation
Phosphate-Binding Proteins metabolism
Phosphate-Binding Proteins genetics

Details

Language :
English
ISSN :
1097-4164
Volume :
84
Issue :
12
Database :
MEDLINE
Journal :
Molecular cell
Publication Type :
Academic Journal
Accession number :
38906113
Full Text :
https://doi.org/10.1016/j.molcel.2024.05.023
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