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Usefulness of high-dose anticoagulants in preventing left ventricular thrombus in acute myocardial infarction.
- Source :
-
The American journal of cardiology [Am J Cardiol] 1985 Jun 01; Vol. 55 (13 Pt 1), pp. 1491-3. - Publication Year :
- 1985
-
Abstract
- Fifty-three patients with a suspected first anterior wall acute myocardial infarction (AMI) were randomized to intervention with intravenous heparin followed by oral warfarin (26 patients) or matching placebo (27 patients). The regimen was started within 12 hours after the onset of AMI. Anticoagulation was maintained at a therapeutic level (for heparin, activated partial thromboplastin time 70 to 140 seconds; for warfarin, thrombotest 5 to 10%) for 10 days, and no bleeding episodes occurred. The baseline characteristics of the 2 study groups were well matched. In 7 patients in the placebo group and in none in the anticoagulant group, left ventricular thrombus developed during the study, as detected by serial 2-dimensional echocardiography. Early intervention with high-dose anticoagulant drugs may prevent the development of left ventricular thrombus in anterior wall AMI.
- Subjects :
- Aged
Anticoagulants administration & dosage
Clinical Trials as Topic
Coronary Disease etiology
Female
Heparin administration & dosage
Humans
Male
Middle Aged
Myocardial Infarction complications
Warfarin administration & dosage
Anticoagulants therapeutic use
Coronary Disease prevention & control
Myocardial Infarction drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 0002-9149
- Volume :
- 55
- Issue :
- 13 Pt 1
- Database :
- MEDLINE
- Journal :
- The American journal of cardiology
- Publication Type :
- Academic Journal
- Accession number :
- 3890508
- Full Text :
- https://doi.org/10.1016/0002-9149(85)90959-2