Back to Search
Start Over
Cardioprotective effects of early versus late initiated antiretroviral treatment in adolescents with perinatal HIV-1 infection.
- Source :
-
Scientific reports [Sci Rep] 2024 Jun 20; Vol. 14 (1), pp. 14234. Date of Electronic Publication: 2024 Jun 20. - Publication Year :
- 2024
-
Abstract
- Whether, and how, cardioprotective effects of antiretroviral treatment (ART) in adolescents with perinatal HIV infection (APHIV) vary with age at treatment initiation is unknown. We used magnetic resonance imaging to compare cardiac status between APHIV initiated on ART at < 5 years of age (early ART, n = 37) and ≥ 5 years of age (delayed ART, n = 34) versus HIV-uninfected peers (n = 21), reporting z-score mean differences adjusted for confounders. Relative to HIV-uninfected adolescents, APHIV with early ART had higher left ventricular (LV) global circumferential strain (GCS) [adjusted mean (95%CI) z-score: 0.53 (0.13, 0.92)] and maximum indexed left atrium volume (LAVi) [adjusted z-score: 0.55 (0.08, 1.02)]. In contrast, APHIV with delayed ART had greater indexed LV end-diastolic volume (LVEDVi) [adjusted z-score: 0.47 (0.09, 0.86)] and extracellular volume fraction [adjusted z-score: 0.79 (0.20, 1.37)], but lower GCS [adjusted z-score: -0.51 (-0.91, -0.10)] than HIV-uninfected peers. APHIV had distinct albeit subclinical cardiac phenotypes depending on ART initiation age. Changes in early ART suggested comparatively worse diastology with preserved systolic function while delayed ART was associated with comparatively increased diffuse fibrosis and LV dilatation with reduced systolic function. The long-term clinical significance of these changes remains to be determined.<br /> (© 2024. The Author(s).)
- Subjects :
- Humans
Female
Adolescent
Male
HIV-1 drug effects
Magnetic Resonance Imaging
Child
Anti-HIV Agents therapeutic use
Anti-HIV Agents administration & dosage
Anti-Retroviral Agents administration & dosage
Anti-Retroviral Agents therapeutic use
Infectious Disease Transmission, Vertical prevention & control
Child, Preschool
HIV Infections drug therapy
Subjects
Details
- Language :
- English
- ISSN :
- 2045-2322
- Volume :
- 14
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Scientific reports
- Publication Type :
- Academic Journal
- Accession number :
- 38902326
- Full Text :
- https://doi.org/10.1038/s41598-024-65119-9