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Clinical Analysis of Myocardial Injury in Highlanders with Pulmonary Hypertension.
- Source :
-
High altitude medicine & biology [High Alt Med Biol] 2024 Sep; Vol. 25 (3), pp. 205-211. Date of Electronic Publication: 2024 Jun 20. - Publication Year :
- 2024
-
Abstract
- Background: Pulmonary hypertension (PH) is a prevalent adverse cardiovascular event at high-altitude environments. Prolonged exposure to high altitudes may result in myocardial injury, which is associated with poor clinical outcomes. This study aims to investigate the clinical characteristics of myocardial injury in patients with PH at high altitude. Methods: Consecutive patients admitted to a general tertiary hospital at the altitude of 3,650 m were selected into this retrospective study. Clinical and biochemical data were collected, as well as based on cardiac troponin I (cTnI) and echocardiography, patients were divided into myocardial injury group and non-myocardial injury group. Results: A total of 231 patients were enrolled, among whom 29 (12.6%) had myocardial injury. We found that body mass index, left ventricular end-diastolic dimension, and serum level of creatine kinase-MB (CK-MB) in myocardial injury group were significantly higher than non-myocardial injury group. Spearman correlation analysis revealed that cTnI has a significant positive correlation with CK-MB and lactic dehydrogenase instead of aspartate aminotransferase. A receiver operating characteristic curve was drawn to demonstrate that CK-MB could significantly predict the occurrence of myocardial injury with an area under the curve of 0.749, and a level of 3.035 (sensitivity = 59.3%, specificity = 90.5%) was optimal cutoff value. Conclusion: The incidence of myocardial injury in highlanders with PH is significant. CK-MB, as a convenient and efficient marker, has been found to be closely associated with cTnI and plays a predictive role in the occurrence of myocardial injury with PH in individuals exposed to high altitude.
- Subjects :
- Humans
Male
Female
Retrospective Studies
Middle Aged
Adult
Biomarkers blood
ROC Curve
L-Lactate Dehydrogenase blood
China epidemiology
Body Mass Index
Aspartate Aminotransferases blood
Aged
Hypertension, Pulmonary blood
Hypertension, Pulmonary etiology
Hypertension, Pulmonary epidemiology
Altitude
Troponin I blood
Creatine Kinase, MB Form blood
Echocardiography
Subjects
Details
- Language :
- English
- ISSN :
- 1557-8682
- Volume :
- 25
- Issue :
- 3
- Database :
- MEDLINE
- Journal :
- High altitude medicine & biology
- Publication Type :
- Academic Journal
- Accession number :
- 38900692
- Full Text :
- https://doi.org/10.1089/ham.2023.0075