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Correlation of striatal dopamine D2/3 receptor availability with GABA level in the anterior cingulate cortex in healthy controls but not in alcohol-dependent subjects and individuals at high risk: A multimodal magnetic resonance spectroscopy and positron emission tomography study.
- Source :
-
Addiction biology [Addict Biol] 2024 Jun; Vol. 29 (6), pp. e13424. - Publication Year :
- 2024
-
Abstract
- Background: The association of impaired dopaminergic neurotransmission with the development and maintenance of alcohol use disorder is well known. More specifically, reduced dopamine D2/3 receptors in the striatum of subjects with alcohol dependence (AD) compared to healthy controls have been found in previous studies. Furthermore, alterations of gamma-aminobutyric acid (GABA) and glutamate (Glu) levels in the anterior cingulate cortex (ACC) of AD subjects have been documented in several studies. However, the interaction between cortical Glu levels and striatal dopamine D2/3 receptors has not been investigated in AD thus far.<br />Methods: This study investigated dopamine D2/3 receptor availability via 18F-fallypride positron emission tomography (PET) and GABA as well as Glu levels via magnetic resonance spectroscopy (MRS) in 19 detoxified AD subjects, 18 healthy controls (low risk, LR) controls and 19 individuals at high risk (HR) for developing AD, carefully matched for sex, age and smoking status.<br />Results: We found a significant negative correlation between GABA levels in the ACC and dopamine D2/3 receptor availability in the associative striatum of LR but not in AD or HR individuals. Contrary to our expectations, we did not observe a correlation between Glu concentrations in the ACC and striatal D2/3 receptor availability.<br />Conclusions: The results may reflect potential regulatory cortical mechanisms on mesolimbic dopamine receptors and their disruption in AD and individuals at high risk, mirroring complex neurotransmitter interactions associated with the pathogenesis of addiction. This is the first study combining 18F-fallypride PET and MRS in AD subjects and individuals at high risk.<br /> (© 2024 The Author(s). Addiction Biology published by John Wiley & Sons Ltd on behalf of Society for the Study of Addiction.)
- Subjects :
- Humans
Male
Adult
Female
Middle Aged
Corpus Striatum metabolism
Corpus Striatum diagnostic imaging
Case-Control Studies
Glutamic Acid metabolism
Benzamides
Positron-Emission Tomography
Gyrus Cinguli metabolism
Gyrus Cinguli diagnostic imaging
Alcoholism metabolism
Alcoholism diagnostic imaging
Receptors, Dopamine D2 metabolism
Receptors, Dopamine D3 metabolism
gamma-Aminobutyric Acid metabolism
Magnetic Resonance Spectroscopy
Subjects
Details
- Language :
- English
- ISSN :
- 1369-1600
- Volume :
- 29
- Issue :
- 6
- Database :
- MEDLINE
- Journal :
- Addiction biology
- Publication Type :
- Academic Journal
- Accession number :
- 38899357
- Full Text :
- https://doi.org/10.1111/adb.13424