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Stereoselective polar radical crossover for the functionalization of strained-ring systems.
- Source :
-
Communications chemistry [Commun Chem] 2024 Jun 19; Vol. 7 (1), pp. 139. Date of Electronic Publication: 2024 Jun 19. - Publication Year :
- 2024
-
Abstract
- Radical-polar crossover of organoborates is a poweful tool that enables the creation of two C-C bonds simultaneously. Small ring systems have become essential motifs in drug discovery and medicinal chemistry. However, step-economic methods for their selective functionalization remains scarce. Here we present a one-pot strategy that merges a simple preparation of strained organoboron species with the recently popularized polar radical crossover of borate derivatives to stereoselectively access tri-substituted azetidines, cyclobutanes and five-membered carbo- and heterocycles.<br /> (© 2024. The Author(s).)
Details
- Language :
- English
- ISSN :
- 2399-3669
- Volume :
- 7
- Issue :
- 1
- Database :
- MEDLINE
- Journal :
- Communications chemistry
- Publication Type :
- Academic Journal
- Accession number :
- 38898159
- Full Text :
- https://doi.org/10.1038/s42004-024-01221-3