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Hollow magnetic vortex nanorings loaded with quercetin encapsulated in polydopamine: A high-performance, intelligent nanotheranostic platform for enhanced tumor imaging and dual thermal treatment.
- Source :
-
International journal of pharmaceutics [Int J Pharm] 2024 Jul 20; Vol. 660, pp. 124335. Date of Electronic Publication: 2024 Jun 17. - Publication Year :
- 2024
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Abstract
- Nanoparticle-mediated thermotherapeutic research strives innovative, multifunctional, efficient, and safe treatments. Our study introduces a novel nanoplatform: the hollow magnetic vortex nanorings within a polydopamine layer (HMVNp), which exhibit dual functionality as magnetic and photothermal agents. Utilizing a "Dual-mode" approach, combining an alternating magnetic field (AMF) with near-infrared (NIR) laser irradiation, HMVNp demonstrated a significant enhancement in heating efficacy (58 ± 8 %, SAR = 1441 vs 1032 W/g) over traditional solid magnetite nanoparticles coated with polydopamine (SMNp). The unique geometry larger surface area to volume ratio facilitates efficient magnetic vortex dynamics and enhanced heat transfer. Addressing the challenge of heat resistant heat shock protein (Hsp) expression, encapsulated quercetin (Q) within HMVNp leverages tumor acidity and dual-mode thermal therapy to enhance release, showing a 28.8 ± 6.81 % increase in Q loading capacity compared to traditional SMNp. Moreover, HMVNp significantly improves contrast for both magnetic resonance imaging (MRI) and photoacoustic imaging (PAI), with an approximately 62 % transverse relaxation (R2 = 81.5 vs 31.6 mM <superscript>-1</superscript> s <superscript>-1</superscript> [Fe]). In vivo studies showed that while single treatments slowed tumor growth, dual-mode therapy with quercetin significantly reduced tumors and effectively prevented metastases. Our study highlights the potential of HMVNp/Q as a versatile agent in thermotherapeutic interventions, offering improved diagnostic imaging capabilities.<br />Competing Interests: Declaration of competing interest The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.<br /> (Copyright © 2024 Elsevier B.V. All rights reserved.)
- Subjects :
- Animals
Mice
Theranostic Nanomedicine methods
Cell Line, Tumor
Photoacoustic Techniques methods
Magnetite Nanoparticles chemistry
Humans
Female
Mice, Nude
Mice, Inbred BALB C
Neoplasms therapy
Neoplasms drug therapy
Neoplasms diagnostic imaging
Photothermal Therapy methods
Nanoparticles chemistry
Quercetin administration & dosage
Quercetin chemistry
Quercetin pharmacology
Indoles chemistry
Indoles administration & dosage
Polymers chemistry
Magnetic Resonance Imaging methods
Hyperthermia, Induced methods
Subjects
Details
- Language :
- English
- ISSN :
- 1873-3476
- Volume :
- 660
- Database :
- MEDLINE
- Journal :
- International journal of pharmaceutics
- Publication Type :
- Academic Journal
- Accession number :
- 38897488
- Full Text :
- https://doi.org/10.1016/j.ijpharm.2024.124335