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Advances in the study of the influence of photoreceptors on the development of myopia.
- Source :
-
Experimental eye research [Exp Eye Res] 2024 Aug; Vol. 245, pp. 109976. Date of Electronic Publication: 2024 Jun 17. - Publication Year :
- 2024
-
Abstract
- This review examines the pivotal role of photoreceptor cells in ocular refraction development, focusing on dopamine (DA) as a key neurotransmitter. Contrary to the earlier view favoring cone cells, recent studies have highlighted the substantial contributions of both rod and cone cells to the visual signaling pathways that influence ocular refractive development. Notably, rod cells appeared to play a central role. Photoreceptor cells interact intricately with circadian rhythms, color vision pathways, and other neurotransmitters, all of which are crucial for the complex mechanisms driving the development of myopia. This review emphasizes that ocular refractive development results from a coordinated interplay between diverse cell types, signaling pathways, and neurotransmitters. This perspective has significant implications for unraveling the complex mechanisms underlying myopia and aiding in the development of more effective prevention and treatment strategies.<br />Competing Interests: Declaration of competing interest The authors declare they have no competing interests.<br /> (Copyright © 2024 Elsevier Ltd. All rights reserved.)
- Subjects :
- Humans
Animals
Dopamine metabolism
Retinal Cone Photoreceptor Cells physiology
Retinal Cone Photoreceptor Cells pathology
Retinal Rod Photoreceptor Cells physiology
Circadian Rhythm physiology
Signal Transduction physiology
Photoreceptor Cells, Vertebrate physiology
Photoreceptor Cells, Vertebrate pathology
Myopia physiopathology
Myopia metabolism
Myopia etiology
Refraction, Ocular physiology
Subjects
Details
- Language :
- English
- ISSN :
- 1096-0007
- Volume :
- 245
- Database :
- MEDLINE
- Journal :
- Experimental eye research
- Publication Type :
- Academic Journal
- Accession number :
- 38897270
- Full Text :
- https://doi.org/10.1016/j.exer.2024.109976